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Current Drug Delivery
ISSN (Print): 1567-2018
ISSN (Online): 1875-5704
Epub Full Text Article
DOI: 10.2174/1567201811666140605151224      Price:  $95

Effect Of Combination Of Acrylic Polymers On The Release Of Nevirapine Formulated As Extended Release Matrix Pelletsusing Extrusion And Spheronization Technique

Author(s): Anshuli Sharma, Anjaneya Prasad, Kamal Dua and Gurvinder Singh
The aim of the present research work was to formulate and evaluate the extended release matrix pelletsof nevirapine using extrusion and spheronization technique which will be an alternative technique for making extended release dosage forms and to compare the drug release profiles of the formulations with the referenceproduct. In vitro dissolutions were carried out in 0.04M Phosphate buffer pH6.8 with 2% w/vSLS (sodium lauryl sulphate) for 24 hours with USP type I apparatus at 75rpm. The drug release from the optimised formulation was comparable to that of the reference product and follows first order kinetics followed by non-fickian transportmechanism of drug release which confirms the drug release pattern involves complex mixture of diffusion and erosion. The similarity factor, f2 value of optimised formulation was found to be 70, which shows that the developedformulation was comparable to that of the reference product
Extrusion and spheronization, extended release, nevirapine, pellets
Pharma Research, Ranbaxy Laboratories Ltd, Gurgaon, India