Abstract
Chiral phosphonates find many applications in medicine, agriculture, materials science and also in organic synthesis. The rapid growth of asymmetric organocatalysis in the last decade has sparkled the interest of organophosphorus chemists, and a wealth of new methodologies to obtain chiral phosphonic acid derivatives has been developed in recent years. This review surveys the last five years, and it includes methodology to synthesize hydroxyphosphonates, aminophosphonates, asymmetric aldol reactions and Michael addition reactions, cycloadditions and domino processes, as well as applications in target-oriented synthesis involving the Horner-Wadsworth-Emmons olefination reaction and the use of chiral phosphonates as acylating agents.
Keywords: Aldol reaction, asymmetric synthesis, domino reactions, enantioselective catalysis, hydrophosphonylation, Michael addition, organocatalysis, phosphonates.
Call for Papers in Thematic Issues
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
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