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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Facile Synthesis of Novel N4-Substituted 2-(Trifluoromethyl)-tetrahydrobenzothieno[ 2,3-d]pyrimidine Derivatives

Author(s): Fasong Wang, Hui Gao, Ping Yang, Yan Wang and Xinjian Song

Volume 11, Issue 9, 2014

Page: [700 - 705] Pages: 6

DOI: 10.2174/1570178611666140609225422

Price: $65

Abstract

A series of novel N4-substituted 2-(trifluoromethyl)-tetrahydrobenzothieno[2,3-d]pyrimidine derivatives were synthesized by a facile three-step procedure that presented such advantages as easily accessible starting materials, mild reaction conditions, simple protocol and good overall yields. The structures of the title compounds were confirmed by IR, 1H NMR, 13C NMR, EI-MS, elemental analysis, and single-crystal X-ray diffraction.

Keywords: Facile synthesis, crystal structure, Gewald reaction, thieno[2, 3-d]pyrimidines, fluorinated compounds.

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