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Recent Patents on Anti-Infective Drug Discovery
ISSN (Print): 1574-891X
ISSN (Online): 2212-4071
VOLUME: 9
ISSUE: 1
DOI: 10.2174/1574891X09666140616164918









Recent Advances in the Development of Anti-Infective Prophylactic and/or Therapeutic Agents Based on Toll-Like Receptor (TLRs)

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Author(s): Elena C. Junquera, Lourdes Mateos-Hernández, Jose de la Fuente and Jose M.P. de la Lastra
Pages 14-24 (11)
Abstract:
Toll-like receptors (TLRs) are key players in innate immunity. They are able to sense different microorganisms ranging from protozoa to bacteria, fungi or viruses. Innate immune responses can directly influence adaptive immune responses. Therefore, TLRs are considered as relevant targets for therapeutic applications in immune diseases: such as autoimmune disorders, allergy, sepsis, and cancer. We here review the recent patents based on the modulation of the toll-like receptors to develop anti-infective (prophylactic and/or therapeutic) agents.
Keywords:
Agonist, antagonist, anti-infective agents, immune therapy, innate immunity, toll-like receptors, vaccine.
Affiliation:
Instituto de Investigación en Recursos Cinegéticos, IREC (UCLM-CSIC-JCCLM), Ronda Toledo s/n, 13071 Ciudad Real, Spain.