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Current Drug Targets
ISSN (Print): 1389-4501
ISSN (Online): 1873-5592
VOLUME: 15
ISSUE: 8
DOI: 10.2174/1389450115666140617153348      Price:  $58









Synthetic Glycosylated Natural Products Have Satisfactory Activities

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Author(s): Gangliang Huang and Xinya Mei
Pages 780-784 (5)
Abstract:
Many natural products contain sugar residues, which are essential components for great medicinal importance. The sugar moieties can improve water-solubility of natural products and decrease their toxicity. At the same time, the glycosidic residues are crucial for the activities of natural products. Much effort has been expended over the past decades in developing novel and efficient methodologies to synthesize the glycosylated natural products. This review highlights recent developments in the synthesis of glycosylated natural products. The structure-activity relationships of some of these glycosylated natural products, together with the structure characteristics of their interaction with the biological targets, are also involved.
Graphical Abstract:
Keywords:
Activities, glycosylated natural products, recent development, total synthesis.
Affiliation:
College of Chemistry, Chongqing Normal University, Chongqing 401331, China.