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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Synthetic Glycosylated Natural Products Have Satisfactory Activities

Author(s): Gangliang Huang and Xinya Mei

Volume 15, Issue 8, 2014

Page: [780 - 784] Pages: 5

DOI: 10.2174/1389450115666140617153348

Price: $65

Abstract

Many natural products contain sugar residues, which are essential components for great medicinal importance. The sugar moieties can improve water-solubility of natural products and decrease their toxicity. At the same time, the glycosidic residues are crucial for the activities of natural products. Much effort has been expended over the past decades in developing novel and efficient methodologies to synthesize the glycosylated natural products. This review highlights recent developments in the synthesis of glycosylated natural products. The structure-activity relationships of some of these glycosylated natural products, together with the structure characteristics of their interaction with the biological targets, are also involved.

Keywords: Activities, glycosylated natural products, recent development, total synthesis.

Graphical Abstract

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