Neoglycopeptide Synthesis by Suzuki-Miyaura Couplings between Glycosyl Aryl Boronic Acids and Iodopeptides

Title:Neoglycopeptide Synthesis by Suzuki-Miyaura Couplings between Glycosyl Aryl Boronic Acids and Iodopeptides

Volume: 21 Issue: 10

Author(s): Guohua Chen, Xiangying Gu, Lin Chen, Xin Wang, Yue-Lei Chen, Jingkang Shen and Wenbin Zeng

Affiliation:

Keywords: Glycosyl aryl boronic acids, glycopeptides, iodo peptides, neoglycopeptides, Suzuki-Miyaura coupling.

Abstract: Suzuki-Miyaura coupling reaction was applied in the syntheses of neoglycopeptides. This work utilizes new type of glycosyl aryl boronic acid and readily accessible iodo amino acids/iodopeptides. Both carbohydrate and peptide moieties are unprotected and the final product could be isolated directly. The neoglyco amino acid and neoglycopeptide products feature an O-glycosyl biaryl linker between the carbohydrate and peptide moieties.

Cite this article as:

Chen Guohua, Gu Xiangying, Chen Lin, Wang Xin, Chen Yue-Lei, Shen Jingkang and Zeng Wenbin, Neoglycopeptide Synthesis by Suzuki-Miyaura Couplings between Glycosyl Aryl Boronic Acids and Iodopeptides, Protein & Peptide Letters 2014; 21 (10) . https://dx.doi.org/10.2174/0929866521666140626103204