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Current Pharmaceutical Design
ISSN (Print): 1381-6128
ISSN (Online): 1873-4286
Epub Full Text Article
DOI: 10.2174/1381612820666140630085857      Price:  $95









Telomere Recombination and the ALT Pathway: a Therapeutic Perspective for Cancer

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Author(s): Irena Draskovic and Arturo Londono-Vallejo
Abstract:
Telomeres are essential for cell proliferation and tumor cell immortalization requires the presence of a telomere maintenance mechanism. Thus, interfering with this mechanism constitutes a potential means to impede cell proliferation and tumor progression. Many cancer cells rely on telomerase activity to ensure indefinite proliferation capacity and developing therapeutic approaches that target telomerase has attracted much attention in the last couple of decades. Nevertheless, a non-negligible proportion of tumors utilize telomerase-independent, alternative mechanisms to lengthen telomeres (ALT). Here we briefly discuss both our current understanding of ALT mechanisms and the potential to develop a therapeutic approach targeting ALT
Keywords:
Telomere, recombination, ALT-associated PML body, chromatin, orphan receptors, variant repeats, histone 3.3
Affiliation:
Telomeres & Cancer laboratory; “Labellisé LIGUE”; UMR3244; Institut Curie, 26 rue d,Ulm, 75248 Paris, France; UPMC Univ. Paris 06, 75005 Paris, France