Journal Image
Current Stem Cell Research & Therapy
ISSN (Print): 1574-888X
ISSN (Online): 2212-3946
Epub Full Text Article
DOI: 10.2174/1574888X09666140630102202      Price:  $95

The Role of Progenitor Cells in Osteoarthritis Development and Progression

Author(s): Luminita Labusca and Kaveh Mashayekhi
Osteoarthritis (OA) is a global threat for the quality of life and independent living of affected persons as well as for health resources expenditure. Path physiological changes during OA are known to occur in the entire joint compartments (cartilage, synovial subchondral bone, and ligaments), however the incapability of cartilage to heal has been long time regarded as the major cause of progressive joint surface degeneration and lost of function. Along with other structural particularities such as avascularity and lack of lymph vessels, cartilage low cellularity was regarded as a major culprit for the inability to heal. Reports about the presence of progenitor cell population in adult normal as well as in OA cartilage invite to a reconsideration of the mechanisms involved in the onset and propagation of the disease as well as of the causes that are preventing the endogenous progenitors to recompose a functional extracellular matrix. The interplay and deterministic relations between chronic joint inflammatory milieu characteristic to OA, tissue and (progenitor) cells mechanosensitivity and joint overall functional and pathological load, are not yet fully understood. The possibility of assessing this complex correlation at molecular level could derive in biomarkers for early detection and OA causal treatment. The use of local progenitor populations for cartilage regeneration stand as the foundation of therapeutic strategies already in the phase of clinical trials
Biomarkers, mechanosensitivity, osteoarthritis, progenitors, regenerative medicine
Department of Orthopedic Surgery University Hospital Saint Spiridon Iasi Romania Bd. Independentei nr. 1, cod 700111, IASI Romania