QSAR and Docking Based Semi-Synthesis and In Vivo Evaluation of Artemisinin Derivatives for Antimalarial Activity

Title:QSAR and Docking Based Semi-Synthesis and In Vivo Evaluation of Artemisinin Derivatives for Antimalarial Activity

Volume: 15 Issue: 8

Author(s): Dharmendra Kumar Yadav, Sangeeta Dhawan, Akanksha Chauhan, Tabish Qidwai, Pooja Sharma, Rajendra Singh Bhakuni, Om Prakash Dhawan and Feroz Khan

Affiliation:

Keywords: Artemisinin, ADMET, docking, malaria, plasmepsins, p. yoelii nigeriensis, QSAR.

Abstract: To screen the active antimalarial novel artemisinin derivatives, a QSAR modeling approach was used. QSAR model showed high correlation (r²= 0.83 and rCV²= 0.81) and indicated that Connectivity Index (order 1, standard), Connectivity Index (order 2, standard), Dipole Moment (debye), Dipole Vector X (debye) and LUMO Energy (eV) well correlate with activity. High binding likeness on antimalarial target plasmepsin was detected through molecular docking. Active artemisinin derivatives showed significant activity and indicated compliance with standard parameters of oral bioavailability and ADMET. The active artemisinin derivatives namely, β-Artecyclopropylmether HMCP (A3), β– Artepipernoylether (PIP-1) (A4) and 9-(β-Dihydroartemisinoxy)methyl anthracene (A5) were semi-synthesized and characterized based on its ¹H and ¹³C NMR spectroscopic data and later activity tested in vivo on mice infected with multidrug resistant strain of P. yoelii nigeriensis. Predicted results were successfully validated by in vivo experiments.

Cite this article as:

Yadav Kumar Dharmendra, Dhawan Sangeeta, Chauhan Akanksha, Qidwai Tabish, Sharma Pooja, Bhakuni Singh Rajendra, Dhawan Prakash Om and Khan Feroz, QSAR and Docking Based Semi-Synthesis and In Vivo Evaluation of Artemisinin Derivatives for Antimalarial Activity, Current Drug Targets 2014; 15 (8) . https://dx.doi.org/10.2174/1389450115666140630102711