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Current Pharmaceutical Analysis
ISSN (Print): 1573-4129
ISSN (Online): 1875-676X
VOLUME: 10
ISSUE: 4
DOI: 10.2174/1573412910666140630191329      Price:  $58









Platinum Sensor for Quantifying Caffeine in Drug Formulations

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Author(s): Danyelle Medeiros de Araujo, Chrystiane do Nascimento Brito, Severina Denise Sales de Oliveira, Djalma Ribeiro da Silva, Carlos A. Martinez-Huitle and Cícero Flavio Soares Aragao
Pages 231-238 (8)
Abstract:
Caffeine is the oldest consumed psychoactive drug, present in coffee, cocoa, tea, among other products. Several conventional methods are used to analyze caffeine, for example, chromatography and spectrometry, but these methods are expensive when compared to electroanalytical methods. The objective of this study is to study the feasible applicability of electrochemical techniques for quantification of caffeine in medications. Cyclic voltammetry was performed on the platinum electrode in 0.5 M H2SO4 and after that differential pulse voltammetry was performed to obtain the linear relation between caffeine concentration and current. A linear response in the electroanalytical approach exists from 38.05±3.02 to 192.39±1.04 ppm with a limit of detection of about 9.09±0.72 ppm. This sensor may represent a new analytical tool for caffeine analysis, based on existing literature.
Graphical Abstract:
Keywords:
Caffeine, platinum sensor, cyclic voltammetry, drugs.
Affiliation:
Federal University of Rio Grande do Norte, Institute of Chemistry, Lagoa Nova - CEP 59.072- 970 – Natal, RN, Brazil.