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Endocrine, Metabolic & Immune Disorders-Drug Targets
(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)
ISSN (Print): 1871-5303
ISSN (Online): 2212-3873
Epub Full Text Article
DOI: 10.2174/1871530314666140709085159      Price:  $95









The Antibiotic Effects of Vitamin D

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Author(s): Chunxiao Guo and Adrian F. Gombart
Abstract:
The recent discovery that vitamin D regulates expression of the cathelicidin antimicrobial peptide gene has generated renewed interest in using vitamin D to fight infectious diseases. This review describes the historical use of vitamin D or its sources to treat infections, the mechanism of action through which vitamin D mediates its “antibiotic” effects, findings from epidemiological studies associating vitamin D deficiency with increased susceptibility to infection and clinical trials with vitamin D supplementation to treat or prevent infections. Furthermore studies examining an association between vitamin D levels and cathelicidin expression are discussed. The role of cathelcidin throughout the course of infection from the initial encounter of the pathogen to the resolution of tissue damage and inflammation indicate that individuals need to maintain adequate levels of vitamin D for an optimal immune response. In addition, for treating infections, carefully designed randomized, clinical trials that are appropriately powered to detect modest effects, target populations that are severely deficient in vitamin D,and optimize dose, dosing frequency and safety are needed
Keywords:
Antimicrobial peptide, cathelicidin, infection, innate immunity, vitamin D, vitamin D receptor
Affiliation:
Linus Pauling Institute, Department of Biochemistry and Biophysics, Oregon State University, 307 Linus Pauling Science Center, Corvallis, OR 97331