Abstract
Mucosal administration of vaccines is one of the most popular approaches to induce desired immunity against various types of antigen and microbial in central as well as peripheral blood and in most external mucosal surfaces. The oral route is a preferred choice over parenteral route for this purpose mainly due to an ease of administration and therefore, for the possibility of covering large population for mass immunization. Different strategies of mucosal vaccination aimed to prevent colony formation and infection by pathogens and block its development. But a major concern with these vaccines is the degradation of protein components in stomach due to physiological conditions and gastric enzymes. Therefore, surface modified nanoparticles offer a better and stable alternative for efficient delivery and better activation of required immune responses. Natural and synthetic polymers are used to prepare nanoparticulate carrier systems for the development of oral mucosal vaccines. Amongst these, biodegradable polymers based nano-particulate carriers have been explored extensively for the development of delivery systems. Present review summarizes possible approaches and mechanisms for the systemic immunization by oral vaccines and critically discusses various polymers used, different strategies of surface modification to achieve targeting of antigen loaded nanoparticulate carrier at cellular level that are essentially required for a successful mucosal vaccination approach, and future prospects of nanoparticulate system as adjutants in oral mucosal vaccination.
Keywords: Biodegradable polymers, lectins, mucosal immunization, nanocarriers, nanoparticles, oral vaccines.
Current Drug Delivery
Title:Surface Modified Nanoparticulate Carrier Constructs for Oral Mucosal Vaccine Delivery
Volume: 11 Issue: 6
Author(s): Neeraj Mishra, Devendra Singh, Sandeep Sharma and Ashish Baldi
Affiliation:
Keywords: Biodegradable polymers, lectins, mucosal immunization, nanocarriers, nanoparticles, oral vaccines.
Abstract: Mucosal administration of vaccines is one of the most popular approaches to induce desired immunity against various types of antigen and microbial in central as well as peripheral blood and in most external mucosal surfaces. The oral route is a preferred choice over parenteral route for this purpose mainly due to an ease of administration and therefore, for the possibility of covering large population for mass immunization. Different strategies of mucosal vaccination aimed to prevent colony formation and infection by pathogens and block its development. But a major concern with these vaccines is the degradation of protein components in stomach due to physiological conditions and gastric enzymes. Therefore, surface modified nanoparticles offer a better and stable alternative for efficient delivery and better activation of required immune responses. Natural and synthetic polymers are used to prepare nanoparticulate carrier systems for the development of oral mucosal vaccines. Amongst these, biodegradable polymers based nano-particulate carriers have been explored extensively for the development of delivery systems. Present review summarizes possible approaches and mechanisms for the systemic immunization by oral vaccines and critically discusses various polymers used, different strategies of surface modification to achieve targeting of antigen loaded nanoparticulate carrier at cellular level that are essentially required for a successful mucosal vaccination approach, and future prospects of nanoparticulate system as adjutants in oral mucosal vaccination.
Export Options
About this article
Cite this article as:
Mishra Neeraj, Singh Devendra, Sharma Sandeep and Baldi Ashish, Surface Modified Nanoparticulate Carrier Constructs for Oral Mucosal Vaccine Delivery, Current Drug Delivery 2014; 11 (6) . https://dx.doi.org/10.2174/1567201811666140709112040
DOI https://dx.doi.org/10.2174/1567201811666140709112040 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
Call for Papers in Thematic Issues
Advances of natural products, bio-actives and novel drug delivery system against emerging viral infections
Due to the increasing prevalence of viral infections and the ability of these human pathogens to develop resistance to current treatment strategies, there is a great need to find and develop new compounds to combat them. These molecules must have low toxicity, specific activity and high bioavailability. The most suitable ...read more
Electrospun Fibers as Drug Delivery Systems
In recent years, electrospun fibers have attracted considerable attention as potential platforms for drug delivery due to their distinctive properties and adaptability. These fibers feature a notable surface area-to-volume ratio and can be intentionally designed with high porosity, facilitating an increased capacity for drug loading and rendering them suitable for ...read more
Emerging Nanotherapeutics for Mitigation of Neurodegenerative Disorders
Conditions affecting the central nervous system (CNS) present a significant hurdle due to limited access of both treatments and diagnostic tools for the brain. The blood-brain barrier (BBB) acts as a barrier, restricting the passage of molecules from the bloodstream into the brain. The most formidable challenge facing scientists is ...read more
Nanotechnology Based Chemotherapy for the treatment of Head & Neck Cancer
The escalating recurrence rates observed in Head and Neck cancer, particularly within the chemo-therapeutically treated cohort (50-60%), can be attributed to the non-selective nature of current anticancer drug delivery modalities. In this context, nanotechnology-based drug delivery systems emerge as a promising avenue for achieving precise localization of therapeutic agents to ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
CycloSal-Pronucleotides of Brivudine Monophosphate - Highly Active Antiviral Agents
Current Medicinal Chemistry - Anti-Infective Agents The Role of STAT3 Signaling in Mediating Tumor Resistance to Cancer Therapy
Current Drug Targets A Comprehensive Review on Ethnomedicinal, Pharmacological and Phytochemical Basis of Anticancer Medicinal Plants of Pakistan
Current Cancer Drug Targets Disruptive Nanozyme Technology for Futuristic Bio-Medical and Bio-imaging Applications
Current Nanoscience Microwave Assisted Synthesis, Characterization of Some New Isatin and Thiophene Derivatives as Cytotoxic and Chemopreventive Agents
Letters in Drug Design & Discovery Free ISG15 and Protein ISGylation Emerging in SARS-CoV-2 Infection
Current Drug Targets Raf Inhibitors as Therapeutic Agents Against Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Novel Concepts for Anti-Infective Activity of Cytokines, Chemokines and Diverse Agents
Recent Patents on Anti-Infective Drug Discovery Statin-Induced Myotoxicity: Pharmacokinetic Differences among Statins and the Risk of Rhabdomyolysis, with Particular Reference to Pitavastatin
Current Vascular Pharmacology Mining the Adenovirus "Virome" for Systemic Oncolytics
Current Pharmaceutical Biotechnology The Effect of Chemotherapy/Radiotherapy on Cancerous Pattern Recognition by NK Cells
Current Medicinal Chemistry Specific Targeting of Akt Kinase Isoforms: Taking the Precise Path for Prevention and Treatment of Cancer
Current Drug Targets Organoids as <i>Ex Vivo</i> Culture System to Investigate Infection-host Interaction in Gastric Pre-carcinogenesis
Recent Advances in Inflammation & Allergy Drug Discovery Biochemical and Functional Properties of a Lectin Purified from Korean Large Black Soybeans — A Cultivar of Glycine Max
Protein & Peptide Letters Oral Cavity-Associated Immune System: What is New?
Current Immunology Reviews (Discontinued) Therapeutic Intervention in Cancer and Chronic Viral Infections: Antibody Mediated Manipulation of PD-1/PD-L1 Interaction
Reviews on Recent Clinical Trials Long Non-Coding RNAs As Epigenetic Regulators in Cancer
Current Pharmaceutical Design Retracted: Effects of Vitamin K2 on Osteoporosis
Current Pharmaceutical Design Receptor Tryosine Kinase Inhibitors as Potent Weapons in War Against Cancers
Current Pharmaceutical Design Targeting the G2/M Transition for Antitumor Therapy
Letters in Drug Design & Discovery