Describing the Potential Crossreactome between Mumps Virus and Spermatogenesis-Associated Proteins

Title:Describing the Potential Crossreactome between Mumps Virus and Spermatogenesis-Associated Proteins

Volume: 14 Issue: 3

Author(s): Darja Kanduc

Affiliation:

Keywords: Infertility, mumps immunogenicity, peptide crossreactivity, spermatogenesis-associated proteins, sterility.

Abstract: This study documents that mumps virus shares several peptide sequences with human proteins that, when altered, may be involved in oligospermia/azoospermia, sterility and testicular atrophy. Examples are sperm flagellar protein 2 and spermatogenesis and centriole-associated protein 1. The data invite to further investigate crossreactivity as a potential mechanism linking anti-mumps immune responses, alterations of spermatogenesis–associated antigens and male fertility disorders.

Cite this article as:

Kanduc Darja, Describing the Potential Crossreactome between Mumps Virus and Spermatogenesis-Associated Proteins, Endocrine, Metabolic & Immune Disorders - Drug Targets 2014; 14 (3) . https://dx.doi.org/10.2174/1871530314666140715115257