Synthesis and Evaluation of Heterocyclic Scaffold-Based Styrene Conjugates as New Antibacterial Agents

Title:Synthesis and Evaluation of Heterocyclic Scaffold-Based Styrene Conjugates as New Antibacterial Agents

Volume: 12 Issue: 2

Author(s): M. Rudrapal, T. Mariya Babu, T. Ravi Chandra, U. Divya Durga, V. Swathi, B. Usha Naga Chandrika and K. Ravishankar

Affiliation:

Keywords: Antibacterial, benzimidazole, oxazole, pyrazole, styryl, uracil.

Abstract: The conjugation of different substituted styryl (-CH=CH-Aryl) moieties with the biologically relevant heteroaromatic scaffolds such as 4-benzylidene-2-methyloxazol-5-one, 3-methyl-1-phenylpyrazol-5-one, 2-methylbenzimidazole, 6-methyluracil afforded the newer series (four different series, 1A-3C, 2A-C, 3A-C & 4A-C) of styrene derivatives. Newer styrene derivatives were synthesized and characterized by IR, NMR (¹H & ¹³C), Mass spectroscopic/spectrometric methods and elemental analysis. Results of the antibacterial activity study reveal that the synthesized compounds possess in-vitro activity against the tested bacterial strains, which, however, was comparatively very less than that of the standard drug, amikacin sulphate. From the structure-activity relationship study, it could be attributed that the overall antibacterial efficacy of the conjugated series of styrene derivatives is the sum of bio-effectiveness of styryl moieties and heterocyclic scaffolds.

Cite this article as:

Rudrapal M., Babu Mariya T., Chandra Ravi T., Durga Divya U., Swathi V., Chandrika Usha Naga B. and Ravishankar K., Synthesis and Evaluation of Heterocyclic Scaffold-Based Styrene Conjugates as New Antibacterial Agents, Anti-Infective Agents 2014; 12 (2) . https://dx.doi.org/10.2174/2211352512666140715165318