Aim: The aim of the study was to check whether resitin may be a link between oxidative stress, adiposity and atherosclerosis in OSA patients.
Methods: The common carotid artery (CCA) intima-media thickness (IMT), was measured by ultrasonography in 34non-diabetic, non hypertensive patients with untreated OSA. Oxidative stress (urinary 8-isoprostane levels) was measured by mass spectrometry (Cayman Chemical, USA). Insulin resistance was assessed by the homeostasis modelassessment for insulin resistance (HOMA-IR). Resistin plasma levels were determined by an ELISA kit.
Results: Urinary 8-isoprostanes, but not resistin were associated with the IMT after adjustment for CV risk factors, including HOMA-IR. Resistin levels increased with the degree of OSA severity, but did not correlate to markers of insulin resistance (HOMA-IR) or atherosclerosis. They were, however, associated with the time of sleep at SaO2<90% but not with the urinary 8-isoprostane levels.
Conclusion: In non-diabetic, non-hypertensive OSA patients, resistin plasma levels do not correlate to markers of adiposity, insulin resistance or oxidative stress. IMT was associated only with the levels of oxidative stress (8-urinary isoprostanes).