Abstract
N-(α-Alkyloxime-3-phenylpropionyl) proline was designed and synthesized as an acylating agent to modify the 6-OH of 1-O-acetylbritannilactone. Eight intermediates and eight target compounds were obtained. The structures of sixteen novel compounds were characterized by 1HNMR, IR and HRMS. The activities against HL-60 and Bel-7402 cell lines were tested, the IC50 values of compound IVg were 2.7 μM and 4.3 μM, respectively.
Keywords: Acylation compound, antitumor, britannilactone, synthesis.
Medicinal Chemistry
Title:Design, Synthesis, and Antitumor Activity of Novel Acylate of 6-OH at 1- O-acetylbritannilactone
Volume: 11 Issue: 2
Author(s): Shouxin Liu, Jun Feng, He Liu, Junzhang Li and Xia Tian
Affiliation:
Keywords: Acylation compound, antitumor, britannilactone, synthesis.
Abstract: N-(α-Alkyloxime-3-phenylpropionyl) proline was designed and synthesized as an acylating agent to modify the 6-OH of 1-O-acetylbritannilactone. Eight intermediates and eight target compounds were obtained. The structures of sixteen novel compounds were characterized by 1HNMR, IR and HRMS. The activities against HL-60 and Bel-7402 cell lines were tested, the IC50 values of compound IVg were 2.7 μM and 4.3 μM, respectively.
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Cite this article as:
Liu Shouxin, Feng Jun, Liu He, Li Junzhang and Tian Xia, Design, Synthesis, and Antitumor Activity of Novel Acylate of 6-OH at 1- O-acetylbritannilactone, Medicinal Chemistry 2015; 11 (2) . https://dx.doi.org/10.2174/1573406410666140815123216
DOI https://dx.doi.org/10.2174/1573406410666140815123216 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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