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Current Cancer Therapy Reviews
ISSN (Print): 1573-3947
ISSN (Online): 1875-6301
VOLUME: 10
ISSUE: 1
DOI: 10.2174/157339471001140815151936









Nanoparticulate Drug Delivery Systems for Treatment of Hepatocellular Carcinoma

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Author(s): Shruti S. Shrikhande, Darshana S. Jain, Rajani B. Athawale and Amrita N. Bajaj
Pages 22-33 (12)
Abstract:
Hepatocellular carcinoma is one of the most prevalent forms of cancer throughout the globe. Despite this, therapy of HCC continues to be challenging because of the drawbacks of current treatments options. Lately, nanoparticulate based drug delivery systems have been employed for treatment of variety of cancers, including primary hepatic cancer. These nanocarriers can be tailored to meet the desired requirements on the basis of their size, charge, composition and surface properties. Following attachment to a targeting ligand, the deleterious and toxic effects associated with the drug could be reduced to a minimum, along with site selective delivery of antineoplastic agents. This article attempts to present a review of various nanoparticulate delivery systems which have been explored for the remedy of hepatocellular carcinoma.
Keywords:
Asialoglycoprotein receptors, dendrimers, hepatocellular carcinoma, inorganic nanoparticles, Liposomes, magnetic nanoparticles, polymeric nanoparticles, solid lipid nanoparticles.
Affiliation:
C.U.Shah College of Pharmacy, S.N.D.T Women's University, Santacruz (W), Mumbai-400 049, Maharashtra, India.