Abstract
Angiogenesis is a key issue in the carcinogenesis progression. The development of anti-angiogenic targeted therapies has made significant progress over the last decade. Targeting angiogenesis is considered as a part of the treatment of metastatic colorectal cancer. Less data is available for the other gastrointestinal cancers. The objective of this article is to provide a review of the angiogenesis targeting drugs evaluated in gastrointestinal non colorectal cancers. The review is focused on the following 5 common gastrointestinal cancers: gastric, pancreatic, neuroendocrine cancers, biliary cancers, and hepatocellular carcinoma.
Keywords: Angiogenesis, gastro-intestinal cancers, targeted therapy.
Graphical Abstract
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