Abstract
The search for cheap, easy-to-use and effective spermicides and microbicides to help avoid unwanted pregnancies and the transmission of sexually transmitted diseases has been ongoing for many years. This review takes into account compounds designed to act both as microbicides and spermicides for multipurpose prevention, and focuses on the required methodological studies to evaluate their safety, especially cytotoxicity. A comprehensive literature review was conducted on the synthesis, development, advantages and disadvantages of vaginal multi-function compounds. The available data shows that after several setbacks, there is a current interest in the synthesis and in the activity of novel dualfunction substances.. The study of well-known compounds with distinctive mechanisms of action provides a solid starting point to explore the possible development of such strategies. However, a completely safe and efficient compound for commercialization has yet to be identified.
Keywords: Contraception, microbicides, multipurpose prevention compounds, sexually transmitted diseases, sperm, spermicides.
Current Medicinal Chemistry
Title:Spermicidal and Microbicidal Compounds: In Search of an Efficient Multipurpose Strategy
Volume: 21 Issue: 32
Author(s): M. Baptista, R. Tavares and J. Ramalho-Santos
Affiliation:
Keywords: Contraception, microbicides, multipurpose prevention compounds, sexually transmitted diseases, sperm, spermicides.
Abstract: The search for cheap, easy-to-use and effective spermicides and microbicides to help avoid unwanted pregnancies and the transmission of sexually transmitted diseases has been ongoing for many years. This review takes into account compounds designed to act both as microbicides and spermicides for multipurpose prevention, and focuses on the required methodological studies to evaluate their safety, especially cytotoxicity. A comprehensive literature review was conducted on the synthesis, development, advantages and disadvantages of vaginal multi-function compounds. The available data shows that after several setbacks, there is a current interest in the synthesis and in the activity of novel dualfunction substances.. The study of well-known compounds with distinctive mechanisms of action provides a solid starting point to explore the possible development of such strategies. However, a completely safe and efficient compound for commercialization has yet to be identified.
Export Options
About this article
Cite this article as:
Baptista M., Tavares R. and Ramalho-Santos J., Spermicidal and Microbicidal Compounds: In Search of an Efficient Multipurpose Strategy, Current Medicinal Chemistry 2014; 21 (32) . https://dx.doi.org/10.2174/0929867321666140826115929
DOI https://dx.doi.org/10.2174/0929867321666140826115929 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
Current advances in inherited cardiomyopathy
Describe in detail all novel advances in multimodality imaging related to inherited cardiomyopathy diagnosis and prognosis. Shed light to deeper phenotypic characterization. Acknowledge recent advances in genetics, genomics and precision medicineread more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Microenvironmental Interactions in Chronic Lymphocytic Leukemia: Hints for Pathogenesis and Identification of Targets for Rational Therapy
Current Pharmaceutical Design Infrared-Spectroscopy: A Non-Invasive Tool for Medical Diagnostics and Drug Analysis
Current Medicinal Chemistry Stem Cell Lineage Commitment by Electrical Fields and the Potential Application in Drug Discovery
Current Drug Metabolism New Issues for Copper-64: from Precursor to Innovative Pet Tracers in Clinical Oncology
Current Radiopharmaceuticals Optical Coherence Tomography: A Journey from Clinical Research to Daily Interventional Practice
Recent Patents on Medical Imaging Peroxisome Proliferator-Activated Receptor-γ in Vascular Biology
Cardiovascular & Hematological Disorders-Drug Targets Anti-Cytokine Therapeutics: History and Update
Current Pharmaceutical Design Patent Selections
Recent Patents on Anti-Cancer Drug Discovery Clinical, Immunological and Therapeutic Aspects of Autoimmune Encephalitis
Recent Patents on CNS Drug Discovery (Discontinued) Airway Obstruction in a Cancer Patient: Is it Always Cancer?
Current Respiratory Medicine Reviews Epicardial Adipocyte-derived TNF-α Modulates Local Inflammation in Patients with Advanced Coronary Artery Disease
Current Vascular Pharmacology Treatment of Disability in Peripheral Arterial Disease: New Drugs
Current Drug Targets - Cardiovascular & Hematological Disorders L-Arginine Availability as a Pathological Mechanism in Essential Hypertension, Chronic Renal and Heart Failure
Vascular Disease Prevention (Discontinued) Molecular Hydrogen: New Antioxidant and Anti-inflammatory Therapy for Rheumatoid Arthritis and Related Diseases
Current Pharmaceutical Design The Role of STAT 3 in Tissue Fibrosis
Current Chemical Biology Management and Treatment of Dengue and Chikungunya - Natural Products to the Rescue
Combinatorial Chemistry & High Throughput Screening Maternal Sodium Valproate Exposure Alters Neuroendocrine-Cytokines and Oxido-inflammatory Axes in Neonatal Albino Rats
Endocrine, Metabolic & Immune Disorders - Drug Targets Cannabinoids for the Treatment of Schizophrenia: An Overview
Current Topics in Medicinal Chemistry Molecular Actions of Polyhalogenated Arylhydrocarbons (PAHs) in Female Reproduction
Current Medicinal Chemistry Editorial (Thematic Issue: Angiogenesis in the Development of Cardiovascular Diseases)
Current Angiogenesis (Discontinued)