Abstract
The proton is the smallest functional group in organic synthesis and it is extremely challenging to control it in terms of enantioselectivity. In recent years, the use of organocatalysts has witnessed rapid developments and has become the state-of-art in enantioselective protonation of transient enolate. The key prochiral enolate can be generated via various reaction types. Herein we review recent reports of organocatalytic enantioselective protonation of transient enolate, classifying them according to the type of enolate precursors.
Keywords: Asymmetric synthesis, enantioselective protonation, enolates and enols, organocatalysis.
Call for Papers in Thematic Issues
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
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