Abstract
Continuing our research programme to develop the synthesis of small heterocyclic entities, in the present study we prepared carbohydrazides of privileged coumarins through highly attractive Meerwein arylation. The reaction condition is compatible with a wide variety of functional groups present on coumarin and aniline, delivered in moderate to good yields of the target scaffolds. The heterocyclic hydrazide skeletons are challenging to synthesize and have tremendous applications in the drug discovery area. The resulting structural diversity was screened for its antitubercular activity utilizing Mtb H37Rv strains via the MABA assay method. The growth inhibition of the designed diversity was found to be in the range 50–97%. Several molecules were found to be promising for further chemical development and in silico analysis.
Keywords: Coumarin, carbo-hydrazides, Mtb, H37Rv, MABA.
Graphical Abstract
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
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This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
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