Abstract
Cu-catalyzed N-arylation of amides commonly known as Goldberg reaction is an important transformation in organic synthesis for the construction of pharmaceuticals and fine chemicals. This is the first review in this area which exclusively deals with recent developments in Goldberg reactions with special focus on mechanistic aspects, catalyst development as well as on the recent applications of this reaction in drug synthesis.
Keywords: amides, arylations, C-N coupling, catalysis, copper, Goldberg reaction.
Graphical Abstract
Call for Papers in Thematic Issues
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
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