Abstract
In the post-genomic era, more and more interests have been focusing on epigenetics. The histones studded with certain post-translational modifications (PTMs) are becoming one of the cores in protein chemical biology research. The biological generations and functions of these “histone codes”, such as their structural diversity, sophisticated regulations and complex cross-talks, are gradually discovered but still waiting to be deciphered. However, to prepare enough amount of homogeneously modified histones remain a challenge for chemical biologists. To overcome the shortage of traditional expression, protein total synthesis, semi-synthesis, and unnatural amino acid incorporation are becoming major approaches to fulfill this goal. In this review, we will summarize some typical examples for chemical prepared modified histone proteins for further biological study. The introduction of synthetic chemistry into this realm largely exhibited the importance and potential of chemical tools in biological and biomedical fertile grounds.
Keywords: Histone, protein, protein semi synthesis, post-translational modification, protein expression, total synthesis, unnatural amino acid incorporation.
Graphical Abstract
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
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