Microwave Irradiation As a Substitute for Phase Transfer Catalyst in CAlkylation Reactions

Title:Microwave Irradiation As a Substitute for Phase Transfer Catalyst in CAlkylation Reactions

Volume: 2 Issue: 3

Author(s): Gyorgy Keglevich and Alajos Grun

Affiliation:

Keywords: C-alkylation, CH-acidic compounds, green chemistry, microwave irradiation, phase transfer catalysis.

Abstract: In this minireview, the possible utilization of the microwave (MW) technique in solid–liquid (S–L) phase C-alkylations is summarized. In the S–L phase C-alkylation of a series of simple active methylene containing compounds, such as diethyl malonate, ethyl acetoacetate and ethyl cyanoacetate, as well as P=O-containing derivatives, such as tetraethyl methylenebisphosphonate, diethyl cyanomethylphosphonate and diethyl ethoxycarbonylmethylphosphonate, in most of the cases, there is no need to use a phase transfer catalyst, as MW promotes the reaction in itself. Most of the Calkylations was performed under solvent-free conditions. The elimination of the catalyst and solvent from the system means an environmentally friendly (“green”) accomplishment.

Cite this article as:

Keglevich Gyorgy and Grun Alajos, Microwave Irradiation As a Substitute for Phase Transfer Catalyst in CAlkylation Reactions, Current Green Chemistry 2015; 2 (3) . https://dx.doi.org/10.2174/2213346102666141215212108