Abstract
Cardiac hypertrophy can be divided as pathological hypertrophy and physiological hypertrophy. Unlike pathological hypertrophy, physiological hypertrophy is a beneficial adaptive response, which will not cause heart failure and sudden death and can protect adverse cardiac remodeling. Exercise training is widely known to cause physiological hypertrophy. The genomic basis of pathological hypertrophy and heart failure has been well-known and is well-reviewed. In this review, we will review the genomic profiles of physiological hypertrophy and also summarize genes and microRNAs responsible for exercise-induced physiological hypertrophy. With better understanding of physiological hypertrophy, manipulation of genes or miRNAs responsible for physiological hypertrophy will offer exciting avenues for treating heart failure.
Keywords: Exercise, Physiological hypertrophy, Genomics, MicroRNA
Current Genomics
Title:Exercise-induced Physiological Hypertrophy: Insights from Genomics
Volume: 16 Issue: 2
Author(s): Dongchao Lv, Qi Sun, Yuping Deng, Jiahong Xu, Huansen Huang and Junjie Xiao
Affiliation:
Keywords: Exercise, Physiological hypertrophy, Genomics, MicroRNA
Abstract: Cardiac hypertrophy can be divided as pathological hypertrophy and physiological hypertrophy. Unlike pathological hypertrophy, physiological hypertrophy is a beneficial adaptive response, which will not cause heart failure and sudden death and can protect adverse cardiac remodeling. Exercise training is widely known to cause physiological hypertrophy. The genomic basis of pathological hypertrophy and heart failure has been well-known and is well-reviewed. In this review, we will review the genomic profiles of physiological hypertrophy and also summarize genes and microRNAs responsible for exercise-induced physiological hypertrophy. With better understanding of physiological hypertrophy, manipulation of genes or miRNAs responsible for physiological hypertrophy will offer exciting avenues for treating heart failure.
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Cite this article as:
Lv Dongchao, Sun Qi, Deng Yuping, Xu Jiahong, Huang Huansen and Xiao Junjie, Exercise-induced Physiological Hypertrophy: Insights from Genomics, Current Genomics 2015; 16 (2) . https://dx.doi.org/10.2174/1389202916999150120153618
DOI https://dx.doi.org/10.2174/1389202916999150120153618 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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