Abstract
Psychological stress leads to activation and proliferation of microglial cells in different brain regions. These effects are mediated by inflammatory cytokines, as well as stress hormones including glucocorticoids and norepinephrine. Eliminating microglia from the nervous system or blocking their activation prevented the stress-induced impairments on brain cognitive functions. We conclude that microglial cells are important meditators underlying anti-depression therapies.
Keywords: Antidepressant, glucocorticoid, microglia, norepinephrine, stress.
CNS & Neurological Disorders - Drug Targets
Title:Commentary: The Effects of Psychological Stress on Microglial Cells in the Brain
Volume: 14 Issue: 3
Author(s): Ti-Fei Yuan, Gonglin Hou, Ying Zhao and Oscar Arias-Carrion
Affiliation:
Keywords: Antidepressant, glucocorticoid, microglia, norepinephrine, stress.
Abstract: Psychological stress leads to activation and proliferation of microglial cells in different brain regions. These effects are mediated by inflammatory cytokines, as well as stress hormones including glucocorticoids and norepinephrine. Eliminating microglia from the nervous system or blocking their activation prevented the stress-induced impairments on brain cognitive functions. We conclude that microglial cells are important meditators underlying anti-depression therapies.
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Cite this article as:
Yuan Ti-Fei, Hou Gonglin, Zhao Ying and Arias-Carrion Oscar, Commentary: The Effects of Psychological Stress on Microglial Cells in the Brain, CNS & Neurological Disorders - Drug Targets 2015; 14 (3) . https://dx.doi.org/10.2174/1871527314666150123122851
DOI https://dx.doi.org/10.2174/1871527314666150123122851 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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