Abstract
The search for new drugs against fungal infections is a major challenge to current research in mycotic diseases. Among the different types of drugs prevailing in the market antifungal antibiotics have an important role in the control of mycotic diseases. However the need for new, safe and more effective antifungal is a major challenge to the pharmaceutical industry today, especially with the increase in opportunistic infections in the immune-compromised host. Actinomycetes have occupied a prominent position in the pharmaceutical industry for their seemingly unlimited capacity to produce secondary metabolites. The use of Actinomycetes as an anti fungal agent in the past is mostly responsible for its popularity with antibiotic research today. Considering the immense potential of these Actinomycetes in the discovery of novel lead compounds and for exploitation in pharmaceutical, agriculture and other industrial applications, current review discusses about secondary metabolites derived from Actinomycetes and the iron modulation for their use as an effective therapeutic agent.
Keywords: Actinomycetes, antibiotics, antifungal, antimicrobial, iron, secondary metabolites.
The Natural Products Journal
Title:Secondary Metabolites Derived from Actinomycetes: Iron Modulation and Their Therapeutic Potential
Volume: 5 Issue: 2
Author(s): Anil K. Sharma, Vikas Beniwal, Raman Kumar, Kamia Thakur and Rohit Sharma
Affiliation:
Keywords: Actinomycetes, antibiotics, antifungal, antimicrobial, iron, secondary metabolites.
Abstract: The search for new drugs against fungal infections is a major challenge to current research in mycotic diseases. Among the different types of drugs prevailing in the market antifungal antibiotics have an important role in the control of mycotic diseases. However the need for new, safe and more effective antifungal is a major challenge to the pharmaceutical industry today, especially with the increase in opportunistic infections in the immune-compromised host. Actinomycetes have occupied a prominent position in the pharmaceutical industry for their seemingly unlimited capacity to produce secondary metabolites. The use of Actinomycetes as an anti fungal agent in the past is mostly responsible for its popularity with antibiotic research today. Considering the immense potential of these Actinomycetes in the discovery of novel lead compounds and for exploitation in pharmaceutical, agriculture and other industrial applications, current review discusses about secondary metabolites derived from Actinomycetes and the iron modulation for their use as an effective therapeutic agent.
Export Options
About this article
Cite this article as:
Sharma K. Anil, Beniwal Vikas, Kumar Raman, Thakur Kamia and Sharma Rohit, Secondary Metabolites Derived from Actinomycetes: Iron Modulation and Their Therapeutic Potential, The Natural Products Journal 2015; 5 (2) . https://dx.doi.org/10.2174/2210315505666150223232101
DOI https://dx.doi.org/10.2174/2210315505666150223232101 |
Print ISSN 2210-3155 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-3163 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Effectiveness of Antiretroviral Therapy in HIV-1-Infected Active Drug Users Attended in a Drug Abuse Outpatient Treatment Facility Providing a Multidisciplinary Care Strategy
Current HIV Research β-Carboline Alkaloids: Biochemical and Pharmacological Functions
Current Medicinal Chemistry Insights into Antimicrobial Peptides from Spiders and Scorpions
Protein & Peptide Letters Recent Advances in Adenylation Domain Enzymology in Nonribosomal Peptide Biosynthesis
Current Organic Chemistry Therapeutic Proteins and Nanotechnology: Immune Response and Stealth Bioengineered Constructs
Current Drug Metabolism Adipokines, Metabolism and the Immune Response in the Regulation of Inflammation
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Recent Achievements in Understanding Immune Recovery of Children Treated with HAART
Current Pediatric Reviews Recent Progress in the Identification and Development of InhA Direct Inhibitors of Mycobacterium tuberculosis
Mini-Reviews in Medicinal Chemistry Solubility and Permeability Measurement and Applications in Drug Discovery
Combinatorial Chemistry & High Throughput Screening Energy Provisioning and Inflammasome Activation: The Pivotal Role of AMPK in Sterile Inflammation and Associated Metabolic Disorders
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Peptidylprolyl Cis / Trans Isomerases (Immunophilins): Biological Diversity - Targets - Functions
Current Topics in Medicinal Chemistry Combinatorial Approaches to Iminosugars as Glycosidase and Glycosyltransferase Inhibitors
Combinatorial Chemistry & High Throughput Screening Surreptitious TB Infections with Recently Identified DM People: A Cross- Sectional Study
Infectious Disorders - Drug Targets The Contribution of Host Genetics to TB Disease
Current Respiratory Medicine Reviews Assessing and Treating Cognitive Impairment in Schizophrenia: Current and Future
Current Pharmaceutical Design Filling the Pipeline - New Drugs for an Old Disease
Current Topics in Medicinal Chemistry Mur Ligase Inhibitors as Anti-bacterials: A Comprehensive Review
Current Pharmaceutical Design Advanced Techniques for Imaging the Human Spinal Cord: Review of Literature
Current Medical Imaging Editorial [Hot Topic: Carbonic Anhydrase Inhibitors (Guest Editor: Claudiu T. Supuran)]
Current Topics in Medicinal Chemistry A Systematic Review of Lifestyle Modification and Glucose Intolerance in the Prevention of Type 2 Diabetes
Current Diabetes Reviews