Abstract
In the present work Repaglinide loaded ammonio methacrylate copolymer nanoparticles were developed by modified solvent emulsion technique using high pressure homogenizer. An effect of numerous organic solvents, surfactant concentration, drug-polymer ratios and combination of polymers on encapsulation efficiency as well as drug release profile were studied. Sustained released nanoparticles were obtained in the size of less than 400 nm. FE-SEM showed smooth and rigid surface of Eudragit RS nanoparticle’s while porous surface nature was observed in Eudragit RL nanoparticles. No drug-polymer interaction was found. X-RD revealed that the crystallinity of repaglinide was decreased when processed with Eudragit polymers. Eudragit RSPO retained drug for more time than other copolymers. Most of the formulations followed zero order kinetics. Prepared nanoparticles can be used for the treatment of type 2 diabetes mellitus by minimizing dose rate, reducing adverse effects and enhancing patient fulfillment.
Keywords: Drug release study, eudragit RL, eudragit RS, modified emulsification, stability study.
Micro and Nanosystems
Title:Effect of Solvents, Drug/Polymer Ratio and Surfactant Concentration on In Vitro Characteristic of Repaglinide Loaded Poly (Meth) Acrylate Nanoparticles
Volume: 6 Issue: 4
Author(s): A. Lokhande, S. Mishra, R. Kulkarni and J. Naik
Affiliation:
Keywords: Drug release study, eudragit RL, eudragit RS, modified emulsification, stability study.
Abstract: In the present work Repaglinide loaded ammonio methacrylate copolymer nanoparticles were developed by modified solvent emulsion technique using high pressure homogenizer. An effect of numerous organic solvents, surfactant concentration, drug-polymer ratios and combination of polymers on encapsulation efficiency as well as drug release profile were studied. Sustained released nanoparticles were obtained in the size of less than 400 nm. FE-SEM showed smooth and rigid surface of Eudragit RS nanoparticle’s while porous surface nature was observed in Eudragit RL nanoparticles. No drug-polymer interaction was found. X-RD revealed that the crystallinity of repaglinide was decreased when processed with Eudragit polymers. Eudragit RSPO retained drug for more time than other copolymers. Most of the formulations followed zero order kinetics. Prepared nanoparticles can be used for the treatment of type 2 diabetes mellitus by minimizing dose rate, reducing adverse effects and enhancing patient fulfillment.
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Cite this article as:
Lokhande A., Mishra S., Kulkarni R. and Naik J., Effect of Solvents, Drug/Polymer Ratio and Surfactant Concentration on In Vitro Characteristic of Repaglinide Loaded Poly (Meth) Acrylate Nanoparticles, Micro and Nanosystems 2014; 6 (4) . https://dx.doi.org/10.2174/187640290604150302125610
DOI https://dx.doi.org/10.2174/187640290604150302125610 |
Print ISSN 1876-4029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1876-4037 |
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