Abstract
Leishmaniasis is defined as a cluster of infectious diseases caused by protozoan parasites of the genus Leishmania. It is recognized worldwide as a major health problem, showing high endemicity in developing countries. The present review details this complex group of neglected diseases, with important clinical spectrum and large epidemiological diversity, and discusses the evolution of leishmaniasis treatment and the urgent need for less toxic, more specific and effective drugs against these parasites. Finally, the value of natural products and synthetic derivatives as rich sources of antileishmanial drug candidates is demonstrated, indicating a promising approach for the development of novel therapeutic alternatives.
Keywords: Antileishmanial drugs, Leishmania, Leishmaniasis, Leishmaniasis treatment, natural products, neglected diseases, thiourea.
Current Biotechnology
Title:Leishmaniasis: History, Evolution of Treatment and the Need for New Drugs
Volume: 3 Issue: 4
Author(s): Elisama Azevedo Cardoso, Aldo Rodrigues da Silva, Gabriela Cristina de Carvalho, Aline Guerra Manssour Fraga, Maria Leticia de Castro Barbosa, Andre Luis Souza dos Santos, Helena Carla Castro and Viviane Lione
Affiliation:
Keywords: Antileishmanial drugs, Leishmania, Leishmaniasis, Leishmaniasis treatment, natural products, neglected diseases, thiourea.
Abstract: Leishmaniasis is defined as a cluster of infectious diseases caused by protozoan parasites of the genus Leishmania. It is recognized worldwide as a major health problem, showing high endemicity in developing countries. The present review details this complex group of neglected diseases, with important clinical spectrum and large epidemiological diversity, and discusses the evolution of leishmaniasis treatment and the urgent need for less toxic, more specific and effective drugs against these parasites. Finally, the value of natural products and synthetic derivatives as rich sources of antileishmanial drug candidates is demonstrated, indicating a promising approach for the development of novel therapeutic alternatives.
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Cardoso Azevedo Elisama, Silva Rodrigues da Aldo, Carvalho Cristina de Gabriela, Fraga Guerra Manssour Aline, Barbosa Leticia de Castro Maria, Santos Luis Souza dos Andre, Castro Carla Helena and Lione Viviane, Leishmaniasis: History, Evolution of Treatment and the Need for New Drugs, Current Biotechnology 2014; 3 (4) . https://dx.doi.org/10.2174/2211550104666150303231736
DOI https://dx.doi.org/10.2174/2211550104666150303231736 |
Print ISSN 2211-5501 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-551X |
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