Abstract
Strategies for a particular drug delivery are always of great interest to the pharmaceutical industry, and efficient methods of preparing products with controlled particle microstructures are fundamental for the development and application of drug delivery. Supercritical fluid particle design (SCF PD) processes, as a green and effective alternative to traditional methods, have been effectively employed to produce particles with designated microstructures. Combining with research experiences in our research group, this review aims to provide a roadmap of SCF PD for particular drug delivery. For any drug delivery formulations, macroscopic properties (administration methods, drug release behaviour and targeting) are directly influenced by the particle microstructures (morphology, particle size, particle size distribution, crystal form, drug loading, encapsulation efficiency, etc). “Inverse” strategies are introduced at first to obtain the necessary particle microstructures for a particular drug delivery in this paper. Then, how to produce particles with designated microstructures via SCF PD processes is discussed, mainly focusing on the screening and selection of operating parameters according to thermodynamic and fluid dynamic studies. Recent examples of SCF micronization and co-precipitation/encapsulation processes are also summarized with an emphasis on how to tailor the particle microstructures by controlling the operating parameters. Finally, challenges and issues needing further study are briefly suggested for SCD PD.
Keywords: Supercritical fluids, drug delivery, particle design, microstructures, process, operating parameters, thermodynamics, fluid dynamics.
Current Pharmaceutical Design
Title:Tailoring Particle Microstructures via Supercritical CO2 Processes for Particular Drug Delivery
Volume: 21 Issue: 19
Author(s): Guijin Liu, Yanbin Jiang and Xuezhong Wang
Affiliation:
Keywords: Supercritical fluids, drug delivery, particle design, microstructures, process, operating parameters, thermodynamics, fluid dynamics.
Abstract: Strategies for a particular drug delivery are always of great interest to the pharmaceutical industry, and efficient methods of preparing products with controlled particle microstructures are fundamental for the development and application of drug delivery. Supercritical fluid particle design (SCF PD) processes, as a green and effective alternative to traditional methods, have been effectively employed to produce particles with designated microstructures. Combining with research experiences in our research group, this review aims to provide a roadmap of SCF PD for particular drug delivery. For any drug delivery formulations, macroscopic properties (administration methods, drug release behaviour and targeting) are directly influenced by the particle microstructures (morphology, particle size, particle size distribution, crystal form, drug loading, encapsulation efficiency, etc). “Inverse” strategies are introduced at first to obtain the necessary particle microstructures for a particular drug delivery in this paper. Then, how to produce particles with designated microstructures via SCF PD processes is discussed, mainly focusing on the screening and selection of operating parameters according to thermodynamic and fluid dynamic studies. Recent examples of SCF micronization and co-precipitation/encapsulation processes are also summarized with an emphasis on how to tailor the particle microstructures by controlling the operating parameters. Finally, challenges and issues needing further study are briefly suggested for SCD PD.
Export Options
About this article
Cite this article as:
Liu Guijin, Jiang Yanbin and Wang Xuezhong, Tailoring Particle Microstructures via Supercritical CO2 Processes for Particular Drug Delivery, Current Pharmaceutical Design 2015; 21 (19) . https://dx.doi.org/10.2174/1381612821666150416101116
DOI https://dx.doi.org/10.2174/1381612821666150416101116 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Ezetimibe and other Azetidinone Cholesterol Absorption Inhibitors
Current Topics in Medicinal Chemistry Procalcitonin as a Biomarker for Diabetic Foot Ulcer
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Chronic Inflammatory Diseases and the Acute Respiratory Distress Syndrome (ARDS)
Current Pharmaceutical Design Role of Mitochondria on Muscle Cell Death and Meat Tenderization
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Recent Advances on Stearoyl-Coa Desaturase Regulation in Fatty Liver Diseases
Current Drug Metabolism Polymeric Nanocarriers for the Oral Delivery of Bioactives
Current Drug Therapy Inborn Errors of Metabolism Screening in Neonates: Current Perspective with Diagnosis and Therapy
Current Pediatric Reviews Regenerative Dentistry and Stem Cells: A Multilineage Differentiation as a Safe and Useful Alternative Way of Harvesting and Selection Adipose Derived Mesenchymal Stem Cells
Current Drug Targets Obstetric Anaesthesia and Obesity
Current Women`s Health Reviews Glycogen Synthase Kinase-3 in Neurodegeneration and Neuroprotection:Lessons from Lithium
Current Alzheimer Research Anti-Aging Property of G2013 Molecule as a Novel Immunosuppressive Agent on Enzymatic and Non-Enzymatic Oxidative Stress Determinants in Rat Model
Current Drug Discovery Technologies Connecting the Brain and New Drug Targets for Schizophrenia
Current Pharmaceutical Design Prostate Cancer Prevention by Silibinin
Current Cancer Drug Targets Efficacy of Argane Oil on Metabolic Syndrome in a Moroccan Knee Osteoarthritis Population
Current Rheumatology Reviews Nopal (Opuntia spp.) and its Effects on Metabolic Syndrome: New Insights for the Use of a Millenary Plant
Current Pharmaceutical Design Advances in the Diagnosis and Treatment of PCOS
Current Pharmaceutical Design An Evolutionary Approach for Structure-based Design of Natural and Non-natural Peptidic Ligands
Combinatorial Chemistry & High Throughput Screening Redox Regulation of Fertility in Aging Male and the Role of Antioxidants: A Savior or Stressor
Current Pharmaceutical Design Impaired Myocardial MIF/AMPK Activation Aggravates Myocardial Ischemia Reperfusion Injury in High-Fat Diet-Induced Obesity
Endocrine, Metabolic & Immune Disorders - Drug Targets Interfering with Hedgehog Pathway: New Avenues for Targeted Therapy in Rhabdomyosarcoma
Current Drug Targets