Metal-free Synthesis of 2,4,6-Trisubstituted Pyrimidines using α,β-Unsaturated Ketones and Benzamidine via Tandem Annulation-Oxidation Pathway

Title:Metal-free Synthesis of 2,4,6-Trisubstituted Pyrimidines using α,β-Unsaturated Ketones and Benzamidine via Tandem Annulation-Oxidation Pathway

Volume: 12 Issue: 7

Author(s): Kamlesh S. Vadagaonkar, Hanuman P. Kalmode, Kaliyappan Murugan and Atul C. Chaskar

Affiliation:

Keywords: Benzamidine, Metal-free synthesis, Triethyl amine, Tandem [3+3] annulation-oxidation pathway, α, β-Unsaturated ketones.

Abstract: A tandem metal-free synthesis of partly and fully substituted pyrimidines has been accomplished from α,β-unsaturated ketones and benzamidine in presence of triethyl amine. The reaction proceeds via [3+3] annulation-oxidation sequence and the protocol has been found successful for the synthesis of a wide range of pyrimidine derivatives.

Cite this article as:

S. Vadagaonkar Kamlesh, P. Kalmode Hanuman, Murugan Kaliyappan and C. Chaskar Atul, Metal-free Synthesis of 2,4,6-Trisubstituted Pyrimidines using α,β-Unsaturated Ketones and Benzamidine via Tandem Annulation-Oxidation Pathway, Letters in Organic Chemistry 2015; 12 (7) . https://dx.doi.org/10.2174/1570178612666150425000023