Abstract
Penetration of the blood brain barrier (BBB) by appropriate fluorescent probes remains a challenge in optical imaging and diagnostics. We designed, synthesized and observed the in vivo BBB penetration of a LASER syn-bimane probe. Results demonstrate that the Aib transporter unit in our probe may lead a fluorescent bimanyl moiety across the BBB.
Keywords: Blood-brain barrier, fluorescence microscopy, fluorescent probe, LASER dye, syn-bimane.
Medicinal Chemistry
Title:α¯ Aminoisobutyric Acid Leads a Fluorescent syn-bimane LASER Probe Across the Blood-brain Barrier
Volume: 12 Issue: 1
Author(s): Inbal Lapidot, Danny Baranes, Albert Pinhasov, Gary Gellerman, Amnon Albeck, Flavio Grynszpan and Shimon E. Shatzmiller
Affiliation:
Keywords: Blood-brain barrier, fluorescence microscopy, fluorescent probe, LASER dye, syn-bimane.
Abstract: Penetration of the blood brain barrier (BBB) by appropriate fluorescent probes remains a challenge in optical imaging and diagnostics. We designed, synthesized and observed the in vivo BBB penetration of a LASER syn-bimane probe. Results demonstrate that the Aib transporter unit in our probe may lead a fluorescent bimanyl moiety across the BBB.
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Cite this article as:
Lapidot Inbal, Baranes Danny, Pinhasov Albert, Gellerman Gary, Albeck Amnon, Grynszpan Flavio and E. Shatzmiller Shimon, α¯ Aminoisobutyric Acid Leads a Fluorescent syn-bimane LASER Probe Across the Blood-brain Barrier, Medicinal Chemistry 2016; 12 (1) . https://dx.doi.org/10.2174/1573406411666150518105010
DOI https://dx.doi.org/10.2174/1573406411666150518105010 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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