Abstract
Treatment of brain tumour is a major challenge. This is mainly because of the limited bioavailability of chemotherapeutics in the brain. The major hurdle for brain availability of anticancer agents is the blood brain barrier (BBB). BBB is supposed to protect the brain and maintain homeostasis. It allows vital nutrient for normal brain function and effluxes out foreign toxic substance. Advance in knowledge of bidirectional movement across BBB has allowed development of strategies to enhance brain availability of chemotherapeutics for management of brain tumour. In this review we have focussed on various approaches adopted for enhancing delivery of anticancer agents. We have given a critical analysis of the approaches for further research
Keywords: Brain, chemotherapy, delivery, tumour.
Anti-Cancer Agents in Medicinal Chemistry
Title:Brain Delivery of Chemotherapeutics in Brain Cancer
Volume: 16 Issue: 2
Author(s): Bharat B. Subudhi and Vijay K. Singh
Affiliation:
Keywords: Brain, chemotherapy, delivery, tumour.
Abstract: Treatment of brain tumour is a major challenge. This is mainly because of the limited bioavailability of chemotherapeutics in the brain. The major hurdle for brain availability of anticancer agents is the blood brain barrier (BBB). BBB is supposed to protect the brain and maintain homeostasis. It allows vital nutrient for normal brain function and effluxes out foreign toxic substance. Advance in knowledge of bidirectional movement across BBB has allowed development of strategies to enhance brain availability of chemotherapeutics for management of brain tumour. In this review we have focussed on various approaches adopted for enhancing delivery of anticancer agents. We have given a critical analysis of the approaches for further research
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Cite this article as:
Subudhi B. Bharat and Singh K. Vijay, Brain Delivery of Chemotherapeutics in Brain Cancer, Anti-Cancer Agents in Medicinal Chemistry 2016; 16 (2) . https://dx.doi.org/10.2174/1871520615666150611110354
DOI https://dx.doi.org/10.2174/1871520615666150611110354 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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