Abstract
Type 2 diabetes mellitus (T2DM) is a highly prevalent condition and is associated with a number of metabolic risk factors such as excess of weight, impaired lipid profile and higher levels of blood pressure. As other complex diseases, it is strongly related to an environmental component such as sedentarism and unhealthy diet, and also to a genetic component. A cluster of variants (polymorphisms) in a large number of genes seem to interact with nutrients/dietary factors in modulating cardiometabolic parameters in healthy individuals. The role of total calories intake and also different kind of carbohydrates and dietary fats in worsening the excess of weight and/or metabolic profile in patients with diabetes is well known, but the extent to which genetic factors can modify these associations is not yet fully understood. Therefore, the aim of this mini-review is to discuss the interaction of genetics and diet in the T2DM setting, since both are strongly involved in the genesis and development of the disease.
Keywords: Diet, diabetes mellitus, type 2, polymorphism, genetics.
Current Diabetes Reviews
Title:Diet, Cardiometabolic Factors and Type-2 Diabetes Mellitus: The Role of Genetics
Volume: 12 Issue: 4
Author(s): Aline Marcadenti
Affiliation:
Keywords: Diet, diabetes mellitus, type 2, polymorphism, genetics.
Abstract: Type 2 diabetes mellitus (T2DM) is a highly prevalent condition and is associated with a number of metabolic risk factors such as excess of weight, impaired lipid profile and higher levels of blood pressure. As other complex diseases, it is strongly related to an environmental component such as sedentarism and unhealthy diet, and also to a genetic component. A cluster of variants (polymorphisms) in a large number of genes seem to interact with nutrients/dietary factors in modulating cardiometabolic parameters in healthy individuals. The role of total calories intake and also different kind of carbohydrates and dietary fats in worsening the excess of weight and/or metabolic profile in patients with diabetes is well known, but the extent to which genetic factors can modify these associations is not yet fully understood. Therefore, the aim of this mini-review is to discuss the interaction of genetics and diet in the T2DM setting, since both are strongly involved in the genesis and development of the disease.
Export Options
About this article
Cite this article as:
Marcadenti Aline, Diet, Cardiometabolic Factors and Type-2 Diabetes Mellitus: The Role of Genetics, Current Diabetes Reviews 2016; 12 (4) . https://dx.doi.org/10.2174/1573399811666150716112126
DOI https://dx.doi.org/10.2174/1573399811666150716112126 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Genetic and Molecular Basis of QTL of Diabetes in Mouse: Genes and Polymorphisms
Current Genomics Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms
Current Genomics A Target Based Therapeutic Approach Towards Diabetes Mellitus Using Medicinal Plants
Current Diabetes Reviews Metabolic Therapy of Heart Failure
Current Pharmaceutical Design Efficacy and Safety Assessment of Hypertension Management with Coveram (Perindopril/Amlodipine Fixed Combination) in Patients with Previous Angiotensin Receptor Blocker (ARB) Treatment: Arabian Gulf STRONG Study
Current Vascular Pharmacology Syntheses, Transformations and Pharmaceutical Applications of Kynurenic Acid Derivatives
Current Medicinal Chemistry Heart Failure in South Asia
Current Cardiology Reviews Synthesis of Methyl Succinate by Natural-Fibre Immobilized Lipase of Streptomyces sp. STL-D8
Current Biotechnology The Pathogenesis of Susceptibility to Acute Kidney Injury in the Elderly
Current Aging Science Matrix Metalloproteinase Inhibition in Atherosclerosis and Stroke
Current Molecular Medicine Molecular Basis of Obesity: Current Status and Future Prospects
Current Genomics Polycations Selectively Blocking Tissue Factor-Dependent FVII Activation: Collective In Vitro Anticoagulation Studies§
Inflammation & Allergy - Drug Targets (Discontinued) In Silico Bioactivity Prediction of Methoxime-3,4-dephostatin Derivatives on Human PTP1B: Search for Novel Antidiabetic Leads
Letters in Drug Design & Discovery Mediterranean Diet and Longevity
Current Nutrition & Food Science Determinants of Use of Long-term Continuous Electrocardiographic Monitoring for Acute Ischemic Stroke Patients without Atrial Fibrillation at Baseline
Current Neurovascular Research Correction of Murine Diabetic Hyperglycaemia With A Single Systemic Administration of An AAV2/8 Vector Containing A Novel Codon Optimized Human Insulin Gene
Current Gene Therapy Editorial (Thematic Issue: Natural Polyphenols and Diabetes: Understanding their Mechanism of Action)
Current Medicinal Chemistry High Mobility Group Box Protein-1 in HIV-1 Infection: Connecting Microbial Translocation, Cell Death and Immune Activation
Current HIV Research Association of Neutrophil-Lymphocyte Ratio with Mild Cognitive Impairment in Elderly Chinese Adults: A Case-control Study
Current Alzheimer Research Docking Assisted Prediction and Biological Evaluation of Sideritis L. Components with PTP1b Inhibitory Action and Probable Anti-Diabetic Properties
Current Topics in Medicinal Chemistry