In vitro Percutaneous Absorption of Niacinamide and Phytosterols and in vivo Evaluation of their Effect on Skin Barrier Recovery

Alessia      Offerta; Francesco      Bonina; Franco      Gasparri; Andrea      Zanardi; Lucia      Micicchè; Carmelo      Puglia

Abstract

In this study, we evaluated different strategies to optimize the percutaneous absorption of niacinamide (NA) and soy phytosterols (FITO) by making use of solid lipid nanoparticles (SLN) and penetration enhancers, such as the hydrogenated lecithin. The evaluation of the skin permeation of NA and FITO has been effected in vitro using excised human skin (i.e., stratum corneum-epidermis or SCE). Furthermore, we evaluated the in vivo effect that NA and FITO has on skin barrier recovery after the topical application; using the extent of methyl nicotinate (MN)-induced erythema in damaged skin as a parameter to determine the rate of stratum corneum recovery. Results pointed out the importance of these strategies as valid tools for NA and FITO topical delivery. In fact, soy lecithin based formulations were able to increase the percutaneous absorption of the two active ingredients, while SLN guaranteed an interesting delayed and sustained release of FITO. In vivo evaluation showed clearly that the formulation containing both the actives (NA and FITO) is able to recover about 95% of skin barrier integrity eight days after tape stripping. This effect is probably due to the “synergistic effect” of NA and FITO.

Keywords: Emulsion, Emulgel, Franz cell, Niacinamide, SLN, Soy phytosterols.

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Current Drug Delivery

Title:In vitro Percutaneous Absorption of Niacinamide and Phytosterols and in vivo Evaluation of their Effect on Skin Barrier Recovery

Volume: 13 Issue: 1

Author(s): Alessia Offerta, Francesco Bonina, Franco Gasparri, Andrea Zanardi, Lucia Micicchè and Carmelo Puglia

Affiliation:

Keywords: Emulsion, Emulgel, Franz cell, Niacinamide, SLN, Soy phytosterols.

Abstract: In this study, we evaluated different strategies to optimize the percutaneous absorption of niacinamide (NA) and soy phytosterols (FITO) by making use of solid lipid nanoparticles (SLN) and penetration enhancers, such as the hydrogenated lecithin. The evaluation of the skin permeation of NA and FITO has been effected in vitro using excised human skin (i.e., stratum corneum-epidermis or SCE). Furthermore, we evaluated the in vivo effect that NA and FITO has on skin barrier recovery after the topical application; using the extent of methyl nicotinate (MN)-induced erythema in damaged skin as a parameter to determine the rate of stratum corneum recovery. Results pointed out the importance of these strategies as valid tools for NA and FITO topical delivery. In fact, soy lecithin based formulations were able to increase the percutaneous absorption of the two active ingredients, while SLN guaranteed an interesting delayed and sustained release of FITO. In vivo evaluation showed clearly that the formulation containing both the actives (NA and FITO) is able to recover about 95% of skin barrier integrity eight days after tape stripping. This effect is probably due to the “synergistic effect” of NA and FITO.

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Offerta Alessia, Bonina Francesco, Gasparri Franco, Zanardi Andrea, Micicchè Lucia and Puglia Carmelo, In vitro Percutaneous Absorption of Niacinamide and Phytosterols and in vivo Evaluation of their Effect on Skin Barrier Recovery, Current Drug Delivery 2016; 13 (1) . https://dx.doi.org/10.2174/1567201812666150722123218

DOI https://dx.doi.org/10.2174/1567201812666150722123218	Print ISSN 1567-2018
Publisher Name Bentham Science Publisher	Online ISSN 1875-5704

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