Abstract
Osteoarthritis (OA) is the most common form of arthritis and a huge health and financial burden. The prevalence and incidence of OA are likely to rise due to increasing life expectancy. Although the link between aging and OA is well established, little is known about the mechanisms by which aging contributes to OA development. In recent years, progress has been made in understanding the molecular mechanisms of chondrocyte aging and senescence. Aging and senescent chondrocytes display a senescence-associated secretory phenotype (SASP) associated with increased secretion of pro-inflammatory mediators, extracellular matrix degrading enzymes and oxidative stress, all of which can contribute to the development and progression of OA. There is also evidence that autophagy, an essential homeostatic process, declines with aging and during OA. This review will focus on our current understanding of chondrocyte aging, senescence, and autophagy and their potential roles in the development and progression of OA. An understanding of these processes would be very useful in devising strategies to treat OA or to delay its development.
Keywords: Aging, autophagy, chondrocytes, osteoarthritis, senescence.
Current Aging Science
Title:Cellular Aging, Senescence and Autophagy Processes in Osteoarthritis
Volume: 8 Issue: 2
Author(s): Mohamed Benderdour, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Mohit Kapoor, Maria-Victoria Zunzunegui and Hassan Fahmi
Affiliation:
Keywords: Aging, autophagy, chondrocytes, osteoarthritis, senescence.
Abstract: Osteoarthritis (OA) is the most common form of arthritis and a huge health and financial burden. The prevalence and incidence of OA are likely to rise due to increasing life expectancy. Although the link between aging and OA is well established, little is known about the mechanisms by which aging contributes to OA development. In recent years, progress has been made in understanding the molecular mechanisms of chondrocyte aging and senescence. Aging and senescent chondrocytes display a senescence-associated secretory phenotype (SASP) associated with increased secretion of pro-inflammatory mediators, extracellular matrix degrading enzymes and oxidative stress, all of which can contribute to the development and progression of OA. There is also evidence that autophagy, an essential homeostatic process, declines with aging and during OA. This review will focus on our current understanding of chondrocyte aging, senescence, and autophagy and their potential roles in the development and progression of OA. An understanding of these processes would be very useful in devising strategies to treat OA or to delay its development.
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Benderdour Mohamed, Martel-Pelletier Johanne, Pelletier Jean-Pierre, Kapoor Mohit, Zunzunegui Maria-Victoria and Fahmi Hassan, Cellular Aging, Senescence and Autophagy Processes in Osteoarthritis, Current Aging Science 2015; 8 (2) . https://dx.doi.org/10.2174/1874609808666150727111530
DOI https://dx.doi.org/10.2174/1874609808666150727111530 |
Print ISSN 1874-6098 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-6128 |
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