Abstract
Mitochondria produce the majority of cellular energy via the “slow burn” of substrates such as glucose, free fatty acids and ketones. In diabetes, altered mitochondrial energetics and substrate utilisation may explain, in part, an organ’s susceptibility to complications. This is particularly evident at sites such as the kidney, heart, neurons and retina, which have high energy demands and oxygen consumption rates to meet functional requirements. Within this review we highlight the recent research implicating mitochondrial dysfunction, with particular focus on the contribution of mitochondrial reactive oxygen species, on the development and progression of diabetes complications. Finally, we discuss the current strategies which are being assessed to combat mitochondrial dysfunction in diabetes complications.
Keywords: Diabetic complications, mitochondria, nephropathy, networking, oxidative phosphorylation, retinopathy, ROS, superoxide.
Current Drug Targets
Title:Tapping into Mitochondria to Find Novel Targets for Diabetes Complications
Volume: 17 Issue: 12
Author(s): Nicole B. Flemming, Linda A. Gallo, Micheal S. Ward and Josephine M. Forbes
Affiliation:
Keywords: Diabetic complications, mitochondria, nephropathy, networking, oxidative phosphorylation, retinopathy, ROS, superoxide.
Abstract: Mitochondria produce the majority of cellular energy via the “slow burn” of substrates such as glucose, free fatty acids and ketones. In diabetes, altered mitochondrial energetics and substrate utilisation may explain, in part, an organ’s susceptibility to complications. This is particularly evident at sites such as the kidney, heart, neurons and retina, which have high energy demands and oxygen consumption rates to meet functional requirements. Within this review we highlight the recent research implicating mitochondrial dysfunction, with particular focus on the contribution of mitochondrial reactive oxygen species, on the development and progression of diabetes complications. Finally, we discuss the current strategies which are being assessed to combat mitochondrial dysfunction in diabetes complications.
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Cite this article as:
Flemming B. Nicole, Gallo A. Linda, Ward S. Micheal and Forbes M. Josephine, Tapping into Mitochondria to Find Novel Targets for Diabetes Complications, Current Drug Targets 2016; 17 (12) . https://dx.doi.org/10.2174/1389450116666150727114410
DOI https://dx.doi.org/10.2174/1389450116666150727114410 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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