Abstract
Data obtained through high-throughput technologies have gradually revealed that a unique stratified epithelial architecture of human skin along with the antioxidant-response pathways provided vital defensive mechanisms against UV radiation. However, it is noteworthy that skin is a major target for toxic insult by UV radiations that can alter its structure and function. Substantial fraction of information has been added into the existing pool of knowledge related to natural products mediated biological effects in UV exposed skin cells. Accumulating evidence has started to shed light on the potential of these bioactive ingredients as protective natural products in cosmetics against UV photodamage by exerting biological effects mainly through wide ranging intracellular signalling cascades of oxidative stress and modulation of miRNAs. In this review, we have summarized recently emerging scientific evidences addressing underlying mechanisms of UV induced oxidative stress and deregulation of signalling cascades and how natural products can be used tactfully to protect against UV induced harmful effects.
Keywords: Natural products, UV, oxidative stress, DNA damage, DNA repair, protection, miRNA.
Current Pharmaceutical Biotechnology
Title:Natural Products Mediated Regulation of Oxidative Stress and DNA Damage in Ultraviolet Exposed Skin Cells
Volume: 16 Issue: 12
Author(s): Ammad A. Farooqi, Ruei-Nian Li, Hurng-Wern Huang, Muhammad Ismail, Shyng-Shiou F. Yuan, Hui-Min D. Wang, Jing-Ru Liu, Jen-Yang Tang and Hsueh-Wei Chang
Affiliation:
Keywords: Natural products, UV, oxidative stress, DNA damage, DNA repair, protection, miRNA.
Abstract: Data obtained through high-throughput technologies have gradually revealed that a unique stratified epithelial architecture of human skin along with the antioxidant-response pathways provided vital defensive mechanisms against UV radiation. However, it is noteworthy that skin is a major target for toxic insult by UV radiations that can alter its structure and function. Substantial fraction of information has been added into the existing pool of knowledge related to natural products mediated biological effects in UV exposed skin cells. Accumulating evidence has started to shed light on the potential of these bioactive ingredients as protective natural products in cosmetics against UV photodamage by exerting biological effects mainly through wide ranging intracellular signalling cascades of oxidative stress and modulation of miRNAs. In this review, we have summarized recently emerging scientific evidences addressing underlying mechanisms of UV induced oxidative stress and deregulation of signalling cascades and how natural products can be used tactfully to protect against UV induced harmful effects.
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Farooqi A. Ammad, Li Ruei-Nian, Huang Hurng-Wern, Ismail Muhammad, Yuan F. Shyng-Shiou, Wang D. Hui-Min, Liu Jing-Ru, Tang Jen-Yang and Chang Hsueh-Wei, Natural Products Mediated Regulation of Oxidative Stress and DNA Damage in Ultraviolet Exposed Skin Cells, Current Pharmaceutical Biotechnology 2015; 16 (12) . https://dx.doi.org/10.2174/1389201016666150731111308
DOI https://dx.doi.org/10.2174/1389201016666150731111308 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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