Generic placeholder image

Current Clinical Pharmacology

Editor-in-Chief

ISSN (Print): 1574-8847
ISSN (Online): 2212-3938

Statin Therapy and Cognition in Older People: What is the Evidence?

Author(s): Danijela Gnjidic, Vasi Naganathan, Saul Ben Freedman, Christopher-Etherton Beer, Andrew J. McLachlan, Gemma A. Figtree and Sarah N. Hilmer

Volume 10, Issue 3, 2015

Page: [185 - 193] Pages: 9

DOI: 10.2174/157488471003150820152249

Price: $65

Abstract

Whether to start, continue or discontinue statins in older people remains a clinical and ethical dilemma. While there is clinical trial evidence that statins reduce cardiovascular morbidity in older people, recently concerns have been raised about side effects in this population. Adverse effects of statins reported in older people include muscle-related symptoms, diabetes, impaired physical function and cognitive impairment. The cognitive effects of statins are not well understood and remain contentious. In younger and healthier people with baseline intact cognitive function, short-term data suggest no adverse effects of statins on cognition whereas long-term data support a beneficial role for statins in delaying dementia. Insufficient evidence is currently available to establish causality in relation to statins and cognitive function in older people specifically. The objective of this narrative review is to analyse the current evidence in relation to statin therapy and cognition, and discuss challenges in translating the current evidence to older people.

Keywords: Cognitive function, dementia, discontinuing statins, older people, statins.


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy