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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

An Efficient Way to Synthesize N-(β-Nitroalkyl) Amides through Ritter Reaction

Author(s): Ronghua Shi, Wensi Ai, Tao He, Xiaobo Ma, Shan Qian and Zhouyu Wang

Volume 12, Issue 10, 2015

Page: [720 - 726] Pages: 7

DOI: 10.2174/1570178612666150903213036

Price: $65

Abstract

An efficient and simple way to synthesize N-(β-nitroalkyl) amides with broad substrate spectrum was developed. Various β-nitroarylethanols and nitriles were suitable substrate for the protocol. A series of N-(β-nitroalkyl) amides were synthesized through Ritter reaction and the yield is up to 95%.

Keywords: Alcohols, amides, carbocation, catalysis, nitriles.


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