Abstract
Hydroxamic acids attracted much attention due to their ability to coordinate a range of transition metal ions. Siderophores can be highlighted due to their role as iron carriers in biological systems. This chelation ability joined to their occurrence in living organisms lead to their possible use as drugs. One of the most important pharmacological properties is their ability to inhibit enzymes, activity that can give them properties such as antiinflammatory and anti-cancer agents. Another important feature resulting from their ability to form stable chelates is their use as ligands in asymmetric synthesis. In this review, we will discuss the most recent published results covering the above mentioned aspects.
Keywords: Biological activities, histone deacetylases, hydroxamic acids, metalloenzyme inhibitors, stereoselectivity, synthetic pathways.
Current Organic Synthesis
Title:Hydroxamic Acids, Recent Breakthroughs in Stereoselective Synthesis and Biological Evaluations
Volume: 13 Issue: 5
Author(s): Diana C.G.A. Pinto and Artur M.S. Silva
Affiliation:
Keywords: Biological activities, histone deacetylases, hydroxamic acids, metalloenzyme inhibitors, stereoselectivity, synthetic pathways.
Abstract: Hydroxamic acids attracted much attention due to their ability to coordinate a range of transition metal ions. Siderophores can be highlighted due to their role as iron carriers in biological systems. This chelation ability joined to their occurrence in living organisms lead to their possible use as drugs. One of the most important pharmacological properties is their ability to inhibit enzymes, activity that can give them properties such as antiinflammatory and anti-cancer agents. Another important feature resulting from their ability to form stable chelates is their use as ligands in asymmetric synthesis. In this review, we will discuss the most recent published results covering the above mentioned aspects.
Export Options
About this article
Cite this article as:
Pinto C.G.A. Diana and Silva M.S. Artur, Hydroxamic Acids, Recent Breakthroughs in Stereoselective Synthesis and Biological Evaluations, Current Organic Synthesis 2016; 13 (5) . https://dx.doi.org/10.2174/1570179412666150914201333
DOI https://dx.doi.org/10.2174/1570179412666150914201333 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Increasing Sensitivity to Radiotherapy and Chemotherapy by Using Novel Biological Agents that Alter the Tumor Microenvironment
Current Molecular Medicine Green Tea Polyphenols as Proteasome Inhibitors: Implication in Chemoprevention
Current Cancer Drug Targets Autophagy : Moving Benchside Promises to Patient Bedsides
Current Cancer Drug Targets 18F-FAZA PET/CT in the Preoperative Evaluation of NSCLC: Comparison with 18F-FDG and Immunohistochemistry
Current Radiopharmaceuticals Hepatocyte Growth Factor is a Potential Lymphangiogenic Factor; Clinical Implications
Current Signal Transduction Therapy Lapatinib as a Chemotherapeutic Drug
Recent Patents on Anti-Cancer Drug Discovery Neutrophil Elastase as a Target in Lung Cancer
Anti-Cancer Agents in Medicinal Chemistry Gene Therapy in Plastic and Reconstructive Surgery
Current Gene Therapy An Overview on 2-arylquinolin-4(1H)-ones and Related Structures as Tubulin Polymerisation Inhibitors
Current Topics in Medicinal Chemistry Multidisciplinary Cancer Therapy with Telomerase-Specific Oncolytic Adenovirus
Current Cancer Therapy Reviews HPV-mediated Cervical Cancer: A Systematic Review on Immunological Basis, Molecular Biology, and Immune Evasion Mechanisms
Current Drug Targets Allosteric Inhibitors of SHP2: An Updated Patent Review (2015-2020)
Current Medicinal Chemistry Investigation of Targeting Relationship between Micro-Rna-22 and Vegfr3 in Lung Squamous Cell Carcinoma
Combinatorial Chemistry & High Throughput Screening Clinical Significance of Breast Cancer Resistance Protein/ABCG2 in the Management of Malignancy
Clinical Cancer Drugs Radiolabeled Imaging Probes Targeting Angiogenesis for Personalized Medicine
Current Pharmaceutical Design From Test Tube to Clinical Trial; Promising Herbs with NF-κB and COX- 2 Activity
Current Immunology Reviews (Discontinued) Porphyrins in Photodynamic Therapy - A Search for Ideal Photosensitizers
Current Medicinal Chemistry - Anti-Cancer Agents Epidermolysis Bullosa: The Pediatricians Role
Current Pediatric Reviews Abatacept and Glomerular Diseases: The Open Road for the Second Signal as a New Target is Settled Down
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Recent Progress in the Development of Fluorometric Chemosensors to Detect Enzymatic Activity
Current Medicinal Chemistry