Abstract
Recent research suggests an association between the development and progression of chronic kidney disease (CKD) - which affects 10–13% of the general population and leads to high rates of morbidity - and sleep apnea (SA).
SA impacts 2–4% of middle aged adults through one of its three forms: obstructive (OSA), central (CSA) and mixed sleep apnea, respectively. SA is associated with sleep fragmentation and hypoxemia during the apneic phenomena. Sleep fragmentation activates the renin-angiotensin-aldosterone system and the sympathetic nervous system, and alters the cardiovascular hemodynamic. It also results in the production of free radicals. SA is a risk factor for CKD progression because it is associated with glomerular hyper-filtration and may be an independent predictor of proteinuria. More specifically, the treatment of sleep apnea, manifested through one of its three forms - obstructive, central, and mixed, respectively - can reduce the severity of CKD and delay its progression by reducing CKD risk factors.
This paper discusses the mechanisms that link CKD and sleep apnea, and suggests SA treatments with beneficial effects to CKD-related cases. Optimizing sleep duration and quality and treating sleep disorders, especially SA, we can reduce the severity of CKD and the delay of progression.
Keywords: Sleep apnea, Hypertension, Renin-angiotensin-aldosterone system, Autonomic nervous system, Chronic kidney disease.
Current Respiratory Medicine Reviews
Title:The Links Between Sleep Apnea and Chronic Kidney Disease
Volume: 11 Issue: 4
Author(s): Marius Balint Gib, Christophe Aron, Svetlana Ilie, Frederic Wallyn, Macha Tetart and Dumitrita Balint Gib
Affiliation:
Keywords: Sleep apnea, Hypertension, Renin-angiotensin-aldosterone system, Autonomic nervous system, Chronic kidney disease.
Abstract: Recent research suggests an association between the development and progression of chronic kidney disease (CKD) - which affects 10–13% of the general population and leads to high rates of morbidity - and sleep apnea (SA).
SA impacts 2–4% of middle aged adults through one of its three forms: obstructive (OSA), central (CSA) and mixed sleep apnea, respectively. SA is associated with sleep fragmentation and hypoxemia during the apneic phenomena. Sleep fragmentation activates the renin-angiotensin-aldosterone system and the sympathetic nervous system, and alters the cardiovascular hemodynamic. It also results in the production of free radicals. SA is a risk factor for CKD progression because it is associated with glomerular hyper-filtration and may be an independent predictor of proteinuria. More specifically, the treatment of sleep apnea, manifested through one of its three forms - obstructive, central, and mixed, respectively - can reduce the severity of CKD and delay its progression by reducing CKD risk factors.
This paper discusses the mechanisms that link CKD and sleep apnea, and suggests SA treatments with beneficial effects to CKD-related cases. Optimizing sleep duration and quality and treating sleep disorders, especially SA, we can reduce the severity of CKD and the delay of progression.
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Cite this article as:
Gib Balint Marius, Aron Christophe, Ilie Svetlana, Wallyn Frederic, Tetart Macha and Balint Gib Dumitrita, The Links Between Sleep Apnea and Chronic Kidney Disease, Current Respiratory Medicine Reviews 2015; 11 (4) . https://dx.doi.org/10.2174/1573398X11666150915213824
DOI https://dx.doi.org/10.2174/1573398X11666150915213824 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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