Abstract
Benzoxazepine is a bi-cyclic heterocyclic compound of a benzene ring fused to an oxazepine ring. Various benzoxazepine derivatives have been synthesized and evaluated for various biological activities. Some analogs derivatives have shown potent biological activities and may be considered as lead molecule for the development of future drugs. This review highlights the different biological activities like anticonvulsant, antimicrobial, anticancer, antipsychotic agents, calcium antagonists and neuroprotective. Since no comprehensive review on biological potential of benxozapine is available, this review covers all the literature reports with patents by giving emphasis on synthetic schemes and biological activities of the different benzoxazepine analogs.
Keywords: Benzoxazepine, biological activities, lead molecules, synthetic schemes.
Mini-Reviews in Organic Chemistry
Title:Synthesis and Biological Activities of Substituted Benzoxazepine: A Review
Volume: 12 Issue: 4
Author(s): Jaiprakash N. Sangshetti, Ansari Altamash Shakeel Ahmad, Firoz A. Kalam Khan and Zahid Zaheer
Affiliation:
Keywords: Benzoxazepine, biological activities, lead molecules, synthetic schemes.
Abstract: Benzoxazepine is a bi-cyclic heterocyclic compound of a benzene ring fused to an oxazepine ring. Various benzoxazepine derivatives have been synthesized and evaluated for various biological activities. Some analogs derivatives have shown potent biological activities and may be considered as lead molecule for the development of future drugs. This review highlights the different biological activities like anticonvulsant, antimicrobial, anticancer, antipsychotic agents, calcium antagonists and neuroprotective. Since no comprehensive review on biological potential of benxozapine is available, this review covers all the literature reports with patents by giving emphasis on synthetic schemes and biological activities of the different benzoxazepine analogs.
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Sangshetti N. Jaiprakash, Ahmad Altamash Shakeel Ansari, Khan A. Kalam Firoz and Zaheer Zahid, Synthesis and Biological Activities of Substituted Benzoxazepine: A Review, Mini-Reviews in Organic Chemistry 2015; 12 (4) . https://dx.doi.org/10.2174/1570193X12666150930224315
DOI https://dx.doi.org/10.2174/1570193X12666150930224315 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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