Abstract
Lung cancer, characterized by uncontrolled cell growth in tissues of the lung, is one of the leading causes of cancer mortality worldwide. Many etiologic factors for lung cancer tumorigenesis have been identified to date, such as smoking and exposure to radon, cooking fumes and asbestos. Atmospheric pollution has become increasingly heavy in China in recent years. Accordingly, greater numbers of people are paying attention to the air quality around them. PM2.5 (particulate matter with a diameter of 2.5 micrometers or less), which is one of the most important indicators for measuring air quality, can penetrate and be retained in lung tissue. It is believed that PM2.5 may represent a new type of etiological factor for lung cancer. This study constitutes the analysis of the association between PM2.5 and lung cancer. Genes related to small/nonsmall cell lung cancer were evaluated by assigning scores to measure the impact caused by PM2.5. Analyses of small/nonsmall cell lung cancer genes with high scores revealed that it is theoretically possible that PM2.5 is an etiologic factor for lung cancer. Our results provided new insights of the relationship between lung cancers and air pollution.
Keywords: Lung cancer, PM2.5, Protein-protein interaction.
Combinatorial Chemistry & High Throughput Screening
Title:Analysis of the relationship between PM2.5 and lung cancer based on protein-protein interactions
Volume: 19 Issue: 2
Author(s): Yang Shu, Liucun Zhu, Fei Yuan, Xiangyin Kong, Tao Huang and Yu-Dong Cai
Affiliation:
Keywords: Lung cancer, PM2.5, Protein-protein interaction.
Abstract: Lung cancer, characterized by uncontrolled cell growth in tissues of the lung, is one of the leading causes of cancer mortality worldwide. Many etiologic factors for lung cancer tumorigenesis have been identified to date, such as smoking and exposure to radon, cooking fumes and asbestos. Atmospheric pollution has become increasingly heavy in China in recent years. Accordingly, greater numbers of people are paying attention to the air quality around them. PM2.5 (particulate matter with a diameter of 2.5 micrometers or less), which is one of the most important indicators for measuring air quality, can penetrate and be retained in lung tissue. It is believed that PM2.5 may represent a new type of etiological factor for lung cancer. This study constitutes the analysis of the association between PM2.5 and lung cancer. Genes related to small/nonsmall cell lung cancer were evaluated by assigning scores to measure the impact caused by PM2.5. Analyses of small/nonsmall cell lung cancer genes with high scores revealed that it is theoretically possible that PM2.5 is an etiologic factor for lung cancer. Our results provided new insights of the relationship between lung cancers and air pollution.
Export Options
About this article
Cite this article as:
Shu Yang, Zhu Liucun, Yuan Fei, Kong Xiangyin, Huang Tao and Cai Yu-Dong, Analysis of the relationship between PM2.5 and lung cancer based on protein-protein interactions, Combinatorial Chemistry & High Throughput Screening 2016; 19 (2) . https://dx.doi.org/10.2174/1386207319666151110123345
DOI https://dx.doi.org/10.2174/1386207319666151110123345 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
Call for Papers in Thematic Issues
Artificial Intelligence Methods for Biomedical, Biochemical and Bioinformatics Problems
Recently, a large number of technologies based on artificial intelligence have been developed and applied to solve a diverse range of problems in the areas of biomedical, biochemical and bioinformatics problems. By utilizing powerful computing resources and massive amounts of data, methods based on artificial intelligence can significantly improve the ...read more
Eco-friendly Agents for Biological Control of Pathogenic Diseases
The discovery of an alternative biological approach to disease management includes work on medicinal products derived from natural sources as a starting point for the development of eco-friendly agents for these diseases and the injuries they cause, as well as reducing human contact with hazardous chemicals and their residues. We ...read more
Emerging trends in diseases mechanisms, noble drug targets and therapeutic strategies: focus on immunological and inflammatory disorders
Recently infectious and inflammatory diseases have been a key concern worldwide due to tremendous morbidity and mortality world Wide. Recent, nCOVID-9 pandemic is a good example for the emerging infectious disease outbreak. The world is facing many emerging and re-emerging diseases out breaks at present however, there is huge lack ...read more
Exploring Spectral Graph Theory in Combinatorial Chemistry
Scope of the Thematic Issue: Combinatorial chemistry involves the synthesis and analysis of a large number of diverse compounds simultaneously. Traditional methods rely on brute force experimentation, which can be time-consuming and resource-intensive. Spectral Graph Theory, a branch of mathematics dealing with the properties of graphs in relation to the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Neobavaisoflavone Demonstrates Valid Anti-tumor Effects in Non-Small- Cell Lung Cancer by Inhibiting STAT3
Combinatorial Chemistry & High Throughput Screening Allosteric Inhibitors of Bcr-Abl: Towards Novel Myristate-Pocket Binders
Current Pharmaceutical Biotechnology Identification of Disease-Relevant Genes for Molecularly-Targeted Drug Discovery
Current Cancer Drug Targets From the Design to the Clinical Application of Thromboxane Modulators
Current Pharmaceutical Design Recent Developments in the Field of Tumor-Inhibiting Metal Complexes
Current Pharmaceutical Design Trends in Biotechnological Drugs for Cancer Treatment
Recent Patents on Anti-Cancer Drug Discovery Novel and Emerging Drugs for Acute Lymphoblastic Leukemia
Current Cancer Drug Targets N6-Methyladenosine-Related RNA Signature Predicting the Prognosis of Ovarian Cancer
Recent Patents on Anti-Cancer Drug Discovery Aging and Inflammation: Etiological Culprits of Cancer
Current Aging Science The Multiple Roles of The Transcription Factors MAZ and Pur-1, Two Proteins encoded by Housekeeping Genes
Current Genomics Synthesis and Antiproliferative Assay of Norcantharidin Derivatives in Cancer Cells
Medicinal Chemistry Profilin 1 Potentiates Apoptosis Induced by Staurosporine in Cancer Cells
Current Molecular Medicine Cell Cycle and Energy Metabolism in Tumor Cells: Strategies for Drug Therapy
Recent Patents on Anti-Cancer Drug Discovery MicroRNAs in Non-small Cell Lung Cancer: Current Status and Future Therapeutic Promises
Current Pharmaceutical Design Comparison of Luminescence ADP Production Assay and Radiometric Scintillation Proximity Assay for Cdc7 Kinase
Combinatorial Chemistry & High Throughput Screening Pharmacological Activation of p53 in Cancer Cells
Current Pharmaceutical Design Development of Highly Efficient KinExA Immunosensor-Based Assay for the Measurement of Carcinoembryonic Antigen in Serum
Current Analytical Chemistry The Nature of Immunological Reaction in the Peripheral Airways of Cigarette Smokers
Current Respiratory Medicine Reviews Cervical Cancer: Are There Potential New Targets? An Update on Preclinical and Clinical Results
Current Drug Targets Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases
Current Protein & Peptide Science