Abstract
Background: The present study has made great progress in multifunctional nanomaterials, which have great potential in cancer diagnosis and therapy.
Methods: In this paper, we proposed a new multifunctional nanocomposite (HGN@RhB-BSA/DOX) which bovine serum albumin (BSA) and doxorubicin (DOX) were modified onto hollow gold nanosphere (HGN) by the electrostatic interaction, and fluorescent dye Rhodamine B (RhB) was combined with bovine serum albumin (BSA) by coupling agent 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC)/N-hydroxysuccinimide sodium salt (Sulfo-NHS).
Results: Based on absorption spectrometer, fluorescence spectrometer, and ZetaSizer analyzer, the nanocomposite had strong surface plasmon resonance (SPR) absorption near 800 nm and revealed the success of RhB, BSA, and DOX were bound onto HGN. The significant rising of temperature was observed when multifunctional fluorescent drug-loaded nanoparticle were irradiated with near-infrared (NIR) light.
Conclusion: We conclude that the nanocomposite presents a promising for photothermal therapy, fluorescence imaging and drug delivery.
Keywords: Fluorescent dye, hollow gold nanosphere, multi-modal imaging, photothermal therapy.