Abstract
The protein serine/threonine phosphatases-1 and -2A are major cellular phosphatases, playing a fundamental role in organisms from prokaryotes to eukaryotes. They contribute to 90% dephosphorylation in eukaryote proteins. In the eye, both phosphatases are highly expressed and display important functions in regulating normal eye development. Moreover, they are implicated in pathogenesis through modulation of stress-induced apoptosis. Here we review the recent progresses on these aspects.
Keywords: Serine/threonine phosphatases-1 and -2A, eye development, lens differentiation, developmental apoptosis.
Current Molecular Medicine
Title:Regulation of Eye Development by Protein Serine/Threonine Phosphatases-1 and -2A
Volume: 15 Issue: 10
Author(s): L. -L. Gong, D. W. -C. Li, Y. -Z. Liu, W. -B. Liu, Z. -G. Chen, T. -H. Yang, R. -L. Qi, S. Huang, L. Zhang, L. Wang, W. -F. Hu, X. -H. Hu, W. -K. Ji, Z. -F. Wang, Q. Nie, Z. -X. Huang, X. -D. Gong and Y. Yang
Affiliation:
Keywords: Serine/threonine phosphatases-1 and -2A, eye development, lens differentiation, developmental apoptosis.
Abstract: The protein serine/threonine phosphatases-1 and -2A are major cellular phosphatases, playing a fundamental role in organisms from prokaryotes to eukaryotes. They contribute to 90% dephosphorylation in eukaryote proteins. In the eye, both phosphatases are highly expressed and display important functions in regulating normal eye development. Moreover, they are implicated in pathogenesis through modulation of stress-induced apoptosis. Here we review the recent progresses on these aspects.
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Cite this article as:
Gong -L. L., -C. Li W. D., Liu -Z. Y., Liu -B. W., Chen -G. Z., Yang -H. T., Qi -L. R., Huang S., Zhang L., Wang L., Hu -F. W., Hu -H. X., Ji -K. W., Wang -F. Z., Nie Q., Huang -X. Z., Gong -D. X. and Yang Y., Regulation of Eye Development by Protein Serine/Threonine Phosphatases-1 and -2A, Current Molecular Medicine 2015; 15 (10) . https://dx.doi.org/10.2174/156652401510151125125127
DOI https://dx.doi.org/10.2174/156652401510151125125127 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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