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Current Vascular Pharmacology

Editor-in-Chief

ISSN (Print): 1570-1611
ISSN (Online): 1875-6212

Adiponectin: An Endothelium-Derived Vasoprotective Factor?

Author(s): Lei Shen, Ian M. Evans, Domingos Souza, Mats Dreifaldt, Michael R. Dashwood and Mohamed-Ali Vidya

Volume 14, Issue 2, 2016

Page: [168 - 174] Pages: 7

DOI: 10.2174/1570161114666151202210128

Price: $65

Abstract

Adipose tissue (AT) is now widely accepted as a key secretary organ, as well as an energy storage depot. It secretes a series of cytokines, hormones and bioactive molecules: adipokines. Adiponectin is an abundant systemic adipokine that uniquely is reduced in obesity and increases on weight loss, is anti-inflammatory, promotes insulin sensitivity and affords cardiometabolic protection. It was considered a true adipokine, in that it is exclusively generated by the adipocytes of the adipose tissue. However, recent evidence points to it being secreted by a range of other organs. This review summarizes the non-adipose sources of adiponectin especially that derived from the endothelium, its vasoprotective role and intracellular signalling pathways. Endothelium derived adiponectin may potentially be a new target for clinical intervention in cardiovascular disease.

Keywords: Adiponectin, coronary artery bypass grafting, endothelium, perivascular adipose tissue.

Graphical Abstract

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