Antiplasmodial Limonoids from Trichilia rubescens (Meliaceae)

Title:Antiplasmodial Limonoids from Trichilia rubescens (Meliaceae)

Volume: 12 Issue: 7

Author(s): Tsamo T. Armelle, Nangmo K. Pamela, Mkounga Pierre, Ingrid B. Müller, Kirk Marat, Gabriele Sass and Nkengfack A. Ephrem

Affiliation:

Keywords: Trichilia rubescens, meliaceae, limonoids, nortriterpenoid, anti-plasmodial activity.

Abstract: Two new limonoids, named rubescins D-E (1-2) along with eight known compounds, including five havanensin type limonoids, TS1 (3), TS3 (4), rubescins A-C (5-7) and three known phytosterols, -sitosterol, stigmasterol and its 3-O-glucopyranoside derivative were isolated from the roots and stem bark of Trichilia rubescens, collected from Cameroon. The structures of the new compounds were determined by detailed analyses of 1D and 2D NMR spectra, in combination with high-resolution mass spectrometry data and by comparison with related data from literature. Anti-plasmodial activities of some of the isolated limonoids 1, 2, 4, 6 and 7 were evaluated against erythrocytic stages of strain 3D7 Plasmodium falciparum. Compounds 2 and 4 exhibited significant anti-plasmodial in vitro activity with IC50 values of 1.13 and 0.79 M, respectively.

Cite this article as:

Armelle T. Tsamo, Pamela K. Nangmo, Pierre Mkounga, Müller B. Ingrid, Marat Kirk, Sass Gabriele and Ephrem A. Nkengfack, Antiplasmodial Limonoids from Trichilia rubescens (Meliaceae), Medicinal Chemistry 2016; 12 (7) . https://dx.doi.org/10.2174/1573406412666160106154357