Abstract
Mass spectrometry (LC-MS or LC-MS/MS) appears in all phases of drug discovery and drug development areas. Starting with the screening and identification of a therapeutic agent and further measuring its in vivo and in vitro properties include: absorption, distribution, metabolism, excretion and toxicity (ADMET) and also pharmacokinetic (PK) and pharmacodynamic (PD) quantitative parameters of drug candidate. Mass spectrometry also serves as a necessary tool also to confirm purity and stability of analyzed new chemical entities (NCEs)/new molecular entities (NMEs) as well as for the analysis of degradation products from the synthesis and following on every stages of drug discovery.
Keywords: Mass spectrometry, LC-MS, drug discovery, drug development, ADMET.
Medicinal Chemistry
Title:The Current Use of Mass Spectrometry in Combination with Other Separation Techniques in Drug Discovery Arena
Volume: 12 Issue: 5
Author(s): Piotr Kawczak and Tomasz Baczek
Affiliation:
Keywords: Mass spectrometry, LC-MS, drug discovery, drug development, ADMET.
Abstract: Mass spectrometry (LC-MS or LC-MS/MS) appears in all phases of drug discovery and drug development areas. Starting with the screening and identification of a therapeutic agent and further measuring its in vivo and in vitro properties include: absorption, distribution, metabolism, excretion and toxicity (ADMET) and also pharmacokinetic (PK) and pharmacodynamic (PD) quantitative parameters of drug candidate. Mass spectrometry also serves as a necessary tool also to confirm purity and stability of analyzed new chemical entities (NCEs)/new molecular entities (NMEs) as well as for the analysis of degradation products from the synthesis and following on every stages of drug discovery.
Export Options
About this article
Cite this article as:
Kawczak Piotr and Baczek Tomasz, The Current Use of Mass Spectrometry in Combination with Other Separation Techniques in Drug Discovery Arena, Medicinal Chemistry 2016; 12 (5) . https://dx.doi.org/10.2174/1573406412666160106154856
DOI https://dx.doi.org/10.2174/1573406412666160106154856 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Radiosensitizing Potential of Epigenetic Anticancer Drugs
Anti-Cancer Agents in Medicinal Chemistry Vitreous Humor Diffusion Changes in Behçet’s Disease and Multiple Sclerosis
Current Medical Imaging Membrane Permeable Lipophilic Cations as Mitochondrial Directing Groups
Current Topics in Medicinal Chemistry Meet Our Associate Editor:
Current Molecular Medicine Non-Reproductive Effects of Sex Steroids: Their Immunoregulatory Role
Current Topics in Medicinal Chemistry Application of Monoterpenoids and their Derivatives for Treatment of Neurodegenerative Disorders
Current Medicinal Chemistry Resonant Oscillation Language of a Futuristic Nano-Machine-Module: Eliminating Cancer Cells & Alzheimer Aβ Plaques
Current Topics in Medicinal Chemistry The Effectiveness of Dimethyl Fumarate Monotherapy in the Treatment of Relapsing-Remitting Multiple Sclerosis: A Systematic Review and Meta-Analysis
Current Neuropharmacology <i>In-silico</i> Studies and Biological Activity of Potential BACE-1 Inhibitors
Combinatorial Chemistry & High Throughput Screening Disruption of Circadian Rhythms in Critical Illness - A Role of Hyperoxia-Induced Lung Injury
Current Pharmaceutical Design The Association of <i>CYP2D6*4</i> and <i>POR*28</i> Polymorphisms on Mirtazapine Plasma Level in Subjects with Major Depressive Disorder and Anxiety Disorders
Combinatorial Chemistry & High Throughput Screening The Effectiveness of Topical Anti-scarring Agents and a Novel Combined Process on Cutaneous Scar Management
Current Pharmaceutical Design Free Radicals in Diseases and Potential Role of Phytoconstituents-A Cause with Emerging Importance
Current Chemical Biology Dietary Interventions for Diabetic Neuropathy & Nephropathy: A Review
Current Psychopharmacology Molecular Mechanics Force Fields and their Applications in Drug Design
Anti-Infective Agents in Medicinal Chemistry Discovery of Selective Probes and Antagonists for G Protein-Coupled Receptors FPR/FPRL1 and GPR30
Current Topics in Medicinal Chemistry Adult Neurogenesis in Epileptogenesis: An Update for Preclinical Finding and Potential Clinical Translation
Current Neuropharmacology The Anti-Inflammatory and Pharmacological Actions of Oleocanthal, a Phenolic Contained in Extra Virgin Olive Oil
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Human Endogenous Retroviruses in Multiple Sclerosis: Potential for Novel Neuro-Pharmacological Research
Current Neuropharmacology Neuroprotection by the α2-Adrenoceptor Agonist, Dexmedetomidine, in Experimental Stroke Models
Vascular Disease Prevention (Discontinued)