Generic placeholder image

Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

The Current Use of Mass Spectrometry in Combination with Other Separation Techniques in Drug Discovery Arena

Author(s): Piotr Kawczak and Tomasz Baczek

Volume 12, Issue 5, 2016

Page: [404 - 411] Pages: 8

DOI: 10.2174/1573406412666160106154856

Price: $65

Abstract

Mass spectrometry (LC-MS or LC-MS/MS) appears in all phases of drug discovery and drug development areas. Starting with the screening and identification of a therapeutic agent and further measuring its in vivo and in vitro properties include: absorption, distribution, metabolism, excretion and toxicity (ADMET) and also pharmacokinetic (PK) and pharmacodynamic (PD) quantitative parameters of drug candidate. Mass spectrometry also serves as a necessary tool also to confirm purity and stability of analyzed new chemical entities (NCEs)/new molecular entities (NMEs) as well as for the analysis of degradation products from the synthesis and following on every stages of drug discovery.

Keywords: Mass spectrometry, LC-MS, drug discovery, drug development, ADMET.


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy