Abstract
Diels-Alder reactions have emerged as highly powerful transformations for the generation of structurally complex polycyclic scaffolds essentially due to their associated rapidity and atom-economy. Since its discovery in 1928, a better understanding of steric and electronic effects have allowed the development of many different versions including intramolecular [4+2] cycloadditions, hetero-Diels-Alder reactions, and catalytic asymmetric variants, among others. In this chapter, we will give an overview on the application of Diels-Alder reactions in Medicinal Chemistry.
Keywords: Diels-Alder reaction, [4+2] cycloaddition, medicinal chemistry, drug-like molecules, Diels-Alderase.
Current Organic Chemistry
Title:Diels-Alder Cycloaddition in Medicinal Chemistry
Volume: 20 Issue: 22
Author(s): Laure C. Bouchez, Marion Rusch and Marie-Helene Larraufie
Affiliation:
Keywords: Diels-Alder reaction, [4+2] cycloaddition, medicinal chemistry, drug-like molecules, Diels-Alderase.
Abstract: Diels-Alder reactions have emerged as highly powerful transformations for the generation of structurally complex polycyclic scaffolds essentially due to their associated rapidity and atom-economy. Since its discovery in 1928, a better understanding of steric and electronic effects have allowed the development of many different versions including intramolecular [4+2] cycloadditions, hetero-Diels-Alder reactions, and catalytic asymmetric variants, among others. In this chapter, we will give an overview on the application of Diels-Alder reactions in Medicinal Chemistry.
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Cite this article as:
Bouchez C. Laure, Rusch Marion and Larraufie Marie-Helene, Diels-Alder Cycloaddition in Medicinal Chemistry, Current Organic Chemistry 2016; 20 (22) . https://dx.doi.org/10.2174/1385272820666160216000558
DOI https://dx.doi.org/10.2174/1385272820666160216000558 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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